MET
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| MET | MET, AUTS9, HGFR, RCCP2, c-Met,HGFR | MET proto-oncogene, receptor tyrosine kinase |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
Strong increase of RNA abundance in mid inefctin phase after EBOV infection in human. No effect in MARV or in EBOV and MARV infected bat cells. Novel or at least extended exon in humans suggested.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 287 | 366 | 341 | 266 | 465 | 291 | 341 | 337 | 266 |
Read_Max |  | R. aegyptiacus | Transcriptome | 868 | 615 | 428 | 804 | 646 | 581 | 631 | 853 | 547 |
Read_Max |  | R. aegyptiacus | Genome | 889 | 860 | 378 | 598 | 555 | 347 | 555 | 1058 | 633 |
DESeq | | H. sapiens | Genome | 8066.53 | 7910.11 | 8370.51 | 7085.78 | 8224.81 | 6571.4 | 6905.48 | 6832.25 | 8820.47 |
DESeq | | R. aegyptiacus | Transcriptome | 18090.9 | 13986.68 | 11584.83 | 18805.16 | 17975.81 | 14959.05 | 17958.57 | 18052.83 | 13976.22 |
DESeq | | R. aegyptiacus | Genome | 16784.75 | 17831.12 | 10762.79 | 14083.49 | 16909.43 | 13516.21 | 16574.48 | 16082.53 | 12396.8 |