MET

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MET MET, AUTS9, HGFR, RCCP2, c-Met,HGFR MET proto-oncogene, receptor tyrosine kinase pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.

Strong increase of RNA abundance in mid inefctin phase after EBOV infection in human. No effect in MARV or in EBOV and MARV infected bat cells. Novel or at least extended exon in humans suggested.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome287 366 341 266 465 291 341 337 266
Read_Max
batR. aegyptiacusTranscriptome 868 615 428 804 646 581 631 853 547
Read_Max
bat_genomeR. aegyptiacusGenome 889 860 378 598 555 347 555 1058 633
DESeq
humanH. sapiensGenome 8066.53 7910.11 8370.51 7085.78 8224.81 6571.4 6905.48 6832.25 8820.47
DESeq
batR. aegyptiacusTranscriptome 18090.9 13986.68 11584.83 18805.16 17975.81 14959.05 17958.57 18052.83 13976.22
DESeq
bat_genomeR. aegyptiacusGenome 16784.75 17831.12 10762.79 14083.49 16909.43 13516.21 16574.48 16082.53 12396.8

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8066.53 7085.78 6905.48 -0.19 -0.22 -0.04
7h 7910.11 8224.81 6832.25 0.06 -0.21 -0.27
23h 8370.51 6571.4 8820.47 -0.35 0.08 0.42

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8066.53 7910.11 8370.51 -0.03 0.05 0.08
Ebov 7085.78 8224.81 6571.4 0.22 -0.11 -0.32
Marv 6905.48 6832.25 8820.47 -0.02 0.35 0.37

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 18090.9 18805.16 17958.57 0.06 -0.01 -0.07
7h 13986.68 17975.81 18052.83 0.36 0.37 0.01
23h 11584.83 14959.05 13976.22 0.37 0.27 -0.1

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 18090.9 13986.68 11584.83 -0.37 -0.64 -0.27
Ebov 18805.16 17975.81 14959.05 -0.07 -0.33 -0.27
Marv 17958.57 18052.83 13976.22 0.01 -0.36 -0.37