KRAS
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| KRAS | C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2,KRAS1 | Kirsten rat sarcoma viral oncogene homolog | NM_033360 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
The gene is highly but stably expressed in human cells. The bat cells homolog is also stably and highly expressed.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 292 | 353 | 394 | 345 | 505 | 473 | 443 | 419 | 405 |
Read_Max |  | R. aegyptiacus | Transcriptome | 158 | 108 | 90 | 154 | 125 | 158 | 146 | 178 | 157 |
Read_Max |  | R. aegyptiacus | Genome | 171 | 160 | 78 | 97 | 108 | 90 | 118 | 206 | 178 |
DESeq | | H. sapiens | Genome | 5636.11 | 4968.8 | 5713.71 | 6289.59 | 5877.01 | 6767.47 | 6013.36 | 4377.44 | 7240.56 |
DESeq | | R. aegyptiacus | Transcriptome | 383.26 | 339.57 | 347.92 | 497.29 | 444.51 | 478.34 | 566.1 | 491.77 | 410.36 |
DESeq | | R. aegyptiacus | Genome | 2014.41 | 1957.71 | 1425.96 | 1667.86 | 1968.86 | 2071.69 | 2425.62 | 1949.85 | 1814.27 |