KRAS

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
KRAS C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2,KRAS1 Kirsten rat sarcoma viral oncogene homolog NM_033360 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

The gene is highly but stably expressed in human cells. The bat cells homolog is also stably and highly expressed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome292 353 394 345 505 473 443 419 405
Read_Max
batR. aegyptiacusTranscriptome 158 108 90 154 125 158 146 178 157
Read_Max
bat_genomeR. aegyptiacusGenome 171 160 78 97 108 90 118 206 178
DESeq
humanH. sapiensGenome 5636.11 4968.8 5713.71 6289.59 5877.01 6767.47 6013.36 4377.44 7240.56
DESeq
batR. aegyptiacusTranscriptome 383.26 339.57 347.92 497.29 444.51 478.34 566.1 491.77 410.36
DESeq
bat_genomeR. aegyptiacusGenome 2014.41 1957.71 1425.96 1667.86 1968.86 2071.69 2425.62 1949.85 1814.27

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5636.11 6289.59 6013.36 0.16 0.09 -0.06
7h 4968.8 5877.01 4377.44 0.24 -0.18 -0.42
23h 5713.71 6767.47 7240.56 0.24 0.34 0.1

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5636.11 4968.8 5713.71 -0.18 0.02 0.2
Ebov 6289.59 5877.01 6767.47 -0.1 0.11 0.2
Marv 6013.36 4377.44 7240.56 -0.46 0.27 0.73

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 383.26 497.29 566.1 0.38 0.56 0.19
7h 339.57 444.51 491.77 0.39 0.53 0.15
23h 347.92 478.34 410.36 0.46 0.24 -0.22

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 383.26 339.57 347.92 -0.17 -0.14 0.04
Ebov 497.29 444.51 478.34 -0.16 -0.06 0.11
Marv 566.1 491.77 410.36 -0.2 -0.46 -0.26