TNFRSF1B

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TNFRSF1B p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B,,TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b tumor necrosis factor receptor superfamily, member 1B NM_001066 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the TNF-receptorsuperfamily. This protein and TNF-receptor 1 form a heterocomplex thatmediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2,which possess E3 ubiquitin ligase activity. The function of IAPs inTNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiateTNF-induced apoptosis by the ubiquitination and degradation ofTNF-receptor-associated factor 2, which mediates anti-apoptotic signals.Knockout studies in mice also suggest a role of this protein in protectingneurons from apoptosis by stimulating antioxidative pathways.

This gene was not expressed in human cells, no homolog was found in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1 4 0 1 0 0 2 0 2
Read_Max
batR. aegyptiacusTranscriptome 18 22 31 29 35 53 12 22 25
Read_Max
bat_genomeR. aegyptiacusGenome 20 25 22 21 25 25 9 32 30
DESeq
humanH. sapiensGenome 2.01 2.02 1.0 1.0 1.0 1.0 2.75 1.0 3.17
DESeq
batR. aegyptiacusTranscriptome 99.3 105.38 186.67 151.17 224.4 320.51 85.54 145.59 126.08
DESeq
bat_genomeR. aegyptiacusGenome 226.88 320.35 396.1 230.08 397.34 677.51 172.05 332.24 322.78

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2.01 1.0 2.75 -1.01 0.45 1.46
7h 2.02 1.0 1.0 -1.01 -1.01 0.0
23h 1.0 1.0 3.17 0.0 1.66 1.66

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2.01 2.02 1.0 0.01 -1.01 -1.01
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 2.75 1.0 3.17 -1.46 0.21 1.66

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 99.3 151.17 85.54 0.61 -0.22 -0.82
7h 105.38 224.4 145.59 1.09 0.47 -0.62
23h 186.67 320.51 126.08 0.78 -0.57 -1.35

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 99.3 105.38 186.67 0.09 0.91 0.82
Ebov 151.17 224.4 320.51 0.57 1.08 0.51
Marv 85.54 145.59 126.08 0.77 0.56 -0.21