TNFRSF1B
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| TNFRSF1B | p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B,,TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b | tumor necrosis factor receptor superfamily, member 1B | NM_001066 |  |
NONE |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a member of the TNF-receptorsuperfamily. This protein and TNF-receptor 1 form a heterocomplex thatmediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2,which possess E3 ubiquitin ligase activity. The function of IAPs inTNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiateTNF-induced apoptosis by the ubiquitination and degradation ofTNF-receptor-associated factor 2, which mediates anti-apoptotic signals.Knockout studies in mice also suggest a role of this protein in protectingneurons from apoptosis by stimulating antioxidative pathways.
This gene was not expressed in human cells, no homolog was found in bat cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 1 | 4 | 0 | 1 | 0 | 0 | 2 | 0 | 2 |
Read_Max |  | R. aegyptiacus | Transcriptome | 18 | 22 | 31 | 29 | 35 | 53 | 12 | 22 | 25 |
Read_Max |  | R. aegyptiacus | Genome | 20 | 25 | 22 | 21 | 25 | 25 | 9 | 32 | 30 |
DESeq | | H. sapiens | Genome | 2.01 | 2.02 | 1.0 | 1.0 | 1.0 | 1.0 | 2.75 | 1.0 | 3.17 |
DESeq | | R. aegyptiacus | Transcriptome | 99.3 | 105.38 | 186.67 | 151.17 | 224.4 | 320.51 | 85.54 | 145.59 | 126.08 |
DESeq | | R. aegyptiacus | Genome | 226.88 | 320.35 | 396.1 | 230.08 | 397.34 | 677.51 | 172.05 | 332.24 | 322.78 |