IFNGR2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
IFNGR2	IFNGT1, IFGR2,AF-1	interferon gamma receptor 2 (interferon gamma transducer 1)		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.

The gene IFNGR2 is moderately expressed in human cells and bat cells datasets without significant changes in expression levels.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	40	54	44	49	49	114	64	72	58
Read_Max	R. aegyptiacus	Transcriptome	175	152	102	131	135	210	138	145	238
Read_Max	R. aegyptiacus	Genome	182	130	91	134	105	120	116	169	229
DESeq	H. sapiens	Genome	371.4	401.81	438.84	421.91	392.03	1043.21	419.43	389.48	716.47
DESeq	R. aegyptiacus	Transcriptome	925.99	916.86	793.78	717.97	769.75	1143.03	914.29	747.89	1040.15
DESeq	R. aegyptiacus	Genome	1138.69	894.43	1065.57	1113.88	1061.44	1472.5	1224.62	934.09	1255.18

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	371.4	421.91	419.43	0.18	0.18	-0.01
7h	401.81	392.03	389.48	-0.04	-0.04	-0.01
23h	438.84	1043.21	716.47	1.25	0.71	-0.54

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	371.4	401.81	438.84	0.11	0.24	0.13
Ebov	421.91	392.03	1043.21	-0.11	1.31	1.41
Marv	419.43	389.48	716.47	-0.11	0.77	0.88

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	925.99	717.97	914.29	-0.37	-0.02	0.35
7h	916.86	769.75	747.89	-0.25	-0.29	-0.04
23h	793.78	1143.03	1040.15	0.53	0.39	-0.14

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	925.99	916.86	793.78	-0.01	-0.22	-0.21
Ebov	717.97	769.75	1143.03	0.1	0.67	0.57
Marv	914.29	747.89	1040.15	-0.29	0.19	0.48

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material