WASF1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
WASF1	WAVE, SCAR1, WAVE1,WAVE1, KIAA0269, WAVE	WAS protein family, member 1	NM_003931	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

The expression of this gene is generally higher in human cells than of its homolog in bat cells. However, no differences between infected and non-infected cells could be determined in both species.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	119	101	157	119	162	201	135	152	165
Read_Max	R. aegyptiacus	Transcriptome	34	24	17	31	21	26	28	40	23
Read_Max	R. aegyptiacus	Genome	35	30	15	24	17	15	22	50	23
DESeq	H. sapiens	Genome	1545.51	1585.88	1947.93	1513.55	1749.66	2305.18	1601.02	1719.6	2486.67
DESeq	R. aegyptiacus	Transcriptome	192.55	184.35	126.82	204.28	180.59	190.91	196.78	193.51	172.44
DESeq	R. aegyptiacus	Genome	245.79	242.77	156.21	264.65	220.99	240.2	237.28	241.85	208.05

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1545.51	1513.55	1601.02	-0.03	0.05	0.08
7h	1585.88	1749.66	1719.6	0.14	0.12	-0.03
23h	1947.93	2305.18	2486.67	0.24	0.35	0.11

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1545.51	1585.88	1947.93	0.04	0.33	0.3
Ebov	1513.55	1749.66	2305.18	0.21	0.61	0.4
Marv	1601.02	1719.6	2486.67	0.1	0.64	0.53

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	192.55	204.28	196.78	0.09	0.03	-0.05
7h	184.35	180.59	193.51	-0.03	0.07	0.1
23h	126.82	190.91	172.44	0.59	0.44	-0.15

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	192.55	184.35	126.82	-0.06	-0.6	-0.54
Ebov	204.28	180.59	190.91	-0.18	-0.1	0.08
Marv	196.78	193.51	172.44	-0.02	-0.19	-0.17

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material