WASF1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
WASF1 WAVE, SCAR1, WAVE1,WAVE1, KIAA0269, WAVE WAS protein family, member 1 NM_003931 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

The expression of this gene is generally higher in human cells than of its homolog in bat cells. However, no differences between infected and non-infected cells could be determined in both species.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome119 101 157 119 162 201 135 152 165
Read_Max
batR. aegyptiacusTranscriptome 34 24 17 31 21 26 28 40 23
Read_Max
bat_genomeR. aegyptiacusGenome 35 30 15 24 17 15 22 50 23
DESeq
humanH. sapiensGenome 1545.51 1585.88 1947.93 1513.55 1749.66 2305.18 1601.02 1719.6 2486.67
DESeq
batR. aegyptiacusTranscriptome 192.55 184.35 126.82 204.28 180.59 190.91 196.78 193.51 172.44
DESeq
bat_genomeR. aegyptiacusGenome 245.79 242.77 156.21 264.65 220.99 240.2 237.28 241.85 208.05

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1545.51 1513.55 1601.02 -0.03 0.05 0.08
7h 1585.88 1749.66 1719.6 0.14 0.12 -0.03
23h 1947.93 2305.18 2486.67 0.24 0.35 0.11

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1545.51 1585.88 1947.93 0.04 0.33 0.3
Ebov 1513.55 1749.66 2305.18 0.21 0.61 0.4
Marv 1601.02 1719.6 2486.67 0.1 0.64 0.53

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 192.55 204.28 196.78 0.09 0.03 -0.05
7h 184.35 180.59 193.51 -0.03 0.07 0.1
23h 126.82 190.91 172.44 0.59 0.44 -0.15

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 192.55 184.35 126.82 -0.06 -0.6 -0.54
Ebov 204.28 180.59 190.91 -0.18 -0.1 0.08
Marv 196.78 193.51 172.44 -0.02 -0.19 -0.17