FGFR3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FGFR3 ACH, CD333, CEK2, HSFGFR3EX, JTK4,CEK2 fibroblast growth factor receptor 3 NM_000142 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance.

The gene is upregulated in human cells Ebola and downregulated in late Marburg infection. The bat cells homolog appears to be not expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome344 485 480 393 665 981 500 655 299
Read_Max
batR. aegyptiacusTranscriptome 65 57 61 77 60 38 32 73 84
Read_Max
bat_genomeR. aegyptiacusGenome 72 84 42 61 51 22 29 88 91
DESeq
humanH. sapiensGenome 8516.08 11375.64 10575.58 10455.36 10992.09 16419.76 10164.29 10665.93 6802.35
DESeq
batR. aegyptiacusTranscriptome 603.38 615.51 680.17 826.02 762.09 462.95 472.66 840.43 657.03
DESeq
bat_genomeR. aegyptiacusGenome 916.97 1201.09 858.03 934.16 1174.17 693.17 719.7 1188.63 896.43

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8516.08 10455.36 10164.29 0.3 0.26 -0.04
7h 11375.64 10992.09 10665.93 -0.05 -0.09 -0.04
23h 10575.58 16419.76 6802.35 0.63 -0.64 -1.27

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8516.08 11375.64 10575.58 0.42 0.31 -0.11
Ebov 10455.36 10992.09 16419.76 0.07 0.65 0.58
Marv 10164.29 10665.93 6802.35 0.07 -0.58 -0.65

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 603.38 826.02 472.66 0.45 -0.35 -0.81
7h 615.51 762.09 840.43 0.31 0.45 0.14
23h 680.17 462.95 657.03 -0.56 -0.05 0.51

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 603.38 615.51 680.17 0.03 0.17 0.14
Ebov 826.02 762.09 462.95 -0.12 -0.84 -0.72
Marv 472.66 840.43 657.03 0.83 0.48 -0.36