FGFR3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
FGFR3	ACH, CD333, CEK2, HSFGFR3EX, JTK4,CEK2	fibroblast growth factor receptor 3	NM_000142	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance.

The gene is upregulated in human cells Ebola and downregulated in late Marburg infection. The bat cells homolog appears to be not expressed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	344	485	480	393	665	981	500	655	299
Read_Max	R. aegyptiacus	Transcriptome	65	57	61	77	60	38	32	73	84
Read_Max	R. aegyptiacus	Genome	72	84	42	61	51	22	29	88	91
DESeq	H. sapiens	Genome	8516.08	11375.64	10575.58	10455.36	10992.09	16419.76	10164.29	10665.93	6802.35
DESeq	R. aegyptiacus	Transcriptome	603.38	615.51	680.17	826.02	762.09	462.95	472.66	840.43	657.03
DESeq	R. aegyptiacus	Genome	916.97	1201.09	858.03	934.16	1174.17	693.17	719.7	1188.63	896.43

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8516.08	10455.36	10164.29	0.3	0.26	-0.04
7h	11375.64	10992.09	10665.93	-0.05	-0.09	-0.04
23h	10575.58	16419.76	6802.35	0.63	-0.64	-1.27

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8516.08	11375.64	10575.58	0.42	0.31	-0.11
Ebov	10455.36	10992.09	16419.76	0.07	0.65	0.58
Marv	10164.29	10665.93	6802.35	0.07	-0.58	-0.65

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	603.38	826.02	472.66	0.45	-0.35	-0.81
7h	615.51	762.09	840.43	0.31	0.45	0.14
23h	680.17	462.95	657.03	-0.56	-0.05	0.51

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	603.38	615.51	680.17	0.03	0.17	0.14
Ebov	826.02	762.09	462.95	-0.12	-0.84	-0.72
Marv	472.66	840.43	657.03	0.83	0.48	-0.36

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material