BCL2L1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
BCL2L1	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS,BCLX	BCL2-like 1	NM_138578	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.

This gene was found to be expressed in all probes. A 0.5 times down regulation was observed in 23 h Marburg probes. No other significant difference was found.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	431	400	288	392	501	989	435	608	279
Read_Max	R. aegyptiacus	Transcriptome	49	46	37	60	52	48	36	50	78
Read_Max	R. aegyptiacus	Genome	52	55	32	43	33	28	28	66	76
DESeq	H. sapiens	Genome	6053.19	5827.53	3624.81	5904.04	5099.01	10423.1	5707.22	6084.06	3751.26
DESeq	R. aegyptiacus	Transcriptome	218.6	230.65	261.19	263.8	243.01	291.0	203.46	237.3	359.63
DESeq	R. aegyptiacus	Genome	487.27	518.41	750.92	528.3	555.83	681.42	515.04	497.97	812.53

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6053.19	5904.04	5707.22	-0.04	-0.08	-0.05
7h	5827.53	5099.01	6084.06	-0.19	0.06	0.25
23h	3624.81	10423.1	3751.26	1.52	0.05	-1.47

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6053.19	5827.53	3624.81	-0.05	-0.74	-0.68
Ebov	5904.04	5099.01	10423.1	-0.21	0.82	1.03
Marv	5707.22	6084.06	3751.26	0.09	-0.61	-0.7

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	218.6	263.8	203.46	0.27	-0.1	-0.37
7h	230.65	243.01	237.3	0.08	0.04	-0.03
23h	261.19	291.0	359.63	0.16	0.46	0.31

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	218.6	230.65	261.19	0.08	0.26	0.18
Ebov	263.8	243.01	291.0	-0.12	0.14	0.26
Marv	203.46	237.3	359.63	0.22	0.82	0.6

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material