FGF2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FGF2 BFGF, FGF-2, FGFB, HBGF-2 fibroblast growth factor 2 (basic) NM_002006 pdf

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Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.

Lowly but uniformly expressed in human cells. The bat cells homolog higher but also uniformly expressed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome21 17 20 20 18 32 18 30 22
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 301 234 168 228 160 173 176 295 391
DESeq
humanH. sapiensGenome 217.15 236.59 238.29 196.06 215.62 176.02 222.93 343.92 422.89
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 1325.18 1233.04 1261.94 1225.47 1192.03 1674.84 1218.99 1125.19 1524.88

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 217.15 196.06 222.93 -0.15 0.04 0.19
7h 236.59 215.62 343.92 -0.13 0.54 0.67
23h 238.29 176.02 422.89 -0.44 0.83 1.26

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 217.15 236.59 238.29 0.12 0.13 0.01
Ebov 196.06 215.62 176.02 0.14 -0.16 -0.29
Marv 222.93 343.92 422.89 0.63 0.92 0.3

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA