MYC
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| MYC | MYC, MRTL, MYCC, bHLHe39, c-Myc,c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
This gene is expressed in all probes in human cells and bat cells. It is upregulated in Ebola infected probes in human cells, but not in bat cells. In Marburg infected probes the gene is upregulated after 7 h in human cells (even 2x) and bat cells. It is again downregulated in human cells after 23 h.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 278 | 272 | 153 | 255 | 298 | 512 | 357 | 656 | 334 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 616 | 376 | 347 | 522 | 307 | 355 | 355 | 594 | 602 |
DESeq | | H. sapiens | Genome | 2982.44 | 2490.51 | 1413.79 | 2740.92 | 2348.8 | 3954.03 | 3525.61 | 4817.09 | 3638.18 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 4346.79 | 3414.35 | 3715.54 | 4780.41 | 3682.13 | 4433.17 | 4525.12 | 3465.97 | 3944.48 |