MYC

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MYC MYC, MRTL, MYCC, bHLHe39, c-Myc,c-Myc v-myc avian myelocytomatosis viral oncogene homolog pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

This gene is expressed in all probes in human cells and bat cells. It is upregulated in Ebola infected probes in human cells, but not in bat cells. In Marburg infected probes the gene is upregulated after 7 h in human cells (even 2x) and bat cells. It is again downregulated in human cells after 23 h.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome278 272 153 255 298 512 357 656 334
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 616 376 347 522 307 355 355 594 602
DESeq
humanH. sapiensGenome 2982.44 2490.51 1413.79 2740.92 2348.8 3954.03 3525.61 4817.09 3638.18
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 4346.79 3414.35 3715.54 4780.41 3682.13 4433.17 4525.12 3465.97 3944.48

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2982.44 2740.92 3525.61 -0.12 0.24 0.36
7h 2490.51 2348.8 4817.09 -0.08 0.95 1.04
23h 1413.79 3954.03 3638.18 1.48 1.36 -0.12

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2982.44 2490.51 1413.79 -0.26 -1.08 -0.82
Ebov 2740.92 2348.8 3954.03 -0.22 0.53 0.75
Marv 3525.61 4817.09 3638.18 0.45 0.05 -0.4

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA