PARD6A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PARD6A PAR-6, PAR-6A, TAX40, PAR6alpha, TIP-40 par-6 family cell polarity regulator alpha NM_016948 pdf NONE

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Description

Homo sapiens par-6 partitioning defective 6 homolog alpha (C. elegans) (PARD6A), transcript variant 1 gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

No expression in HG19 and RAE.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome0 0 0 2 2 0 2 2 1
Read_Max
batR. aegyptiacusTranscriptome 5 3 2 2 0 4 2 6 7
Read_Max
bat_genomeR. aegyptiacusGenome 19 22 16 18 13 12 8 35 32
DESeq
humanH. sapiensGenome 1.0 1.0 1.0 3.28 2.63 1.0 4.51 4.2 2.09
DESeq
batR. aegyptiacusTranscriptome 15.28 10.98 3.44 9.24 1.0 7.42 4.34 12.57 14.12
DESeq
bat_genomeR. aegyptiacusGenome 109.14 135.99 172.95 126.4 107.15 163.18 82.09 181.58 183.23

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 3.28 4.51 1.71 2.17 0.46
7h 1.0 2.63 4.2 1.4 2.07 0.68
23h 1.0 1.0 2.09 0.0 1.06 1.06

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 3.28 2.63 1.0 -0.32 -1.71 -1.4
Marv 4.51 4.2 2.09 -0.1 -1.11 -1.01

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 15.28 9.24 4.34 -0.73 -1.82 -1.09
7h 10.98 1.0 12.57 -3.46 0.2 3.65
23h 3.44 7.42 14.12 1.11 2.04 0.93

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 15.28 10.98 3.44 -0.48 -2.15 -1.67
Ebov 9.24 1.0 7.42 -3.21 -0.32 2.89
Marv 4.34 12.57 14.12 1.53 1.7 0.17