CFLAR
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| CFLAR | c-FLIP,CASH, FLIP,CASP8AP1,CASH, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT, c-FLIP | CASP8 and FADD-like apoptosis regulator | NM_003879 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.
This gene was found to be with 3.5 times up-regulation in Ebola-7 h probe and then 0.5 down-regulation in Ebola-23 h for human cells. But no significantly differential expression of this gene was found in bat cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 241 | 151 | 297 | 120 | 408 | 236 | 191 | 199 | 269 |
Read_Max |  | R. aegyptiacus | Transcriptome | 70 | 52 | 43 | 65 | 52 | 60 | 72 | 75 | 77 |
Read_Max |  | R. aegyptiacus | Genome | 108 | 93 | 68 | 107 | 55 | 52 | 91 | 131 | 141 |
DESeq | | H. sapiens | Genome | 3512.16 | 3712.32 | 3615.87 | 3304.42 | 3467.42 | 2849.97 | 3277.36 | 3105.68 | 3065.14 |
DESeq | | R. aegyptiacus | Transcriptome | 412.67 | 346.83 | 312.49 | 374.59 | 365.66 | 495.02 | 439.29 | 394.28 | 393.74 |
DESeq | | R. aegyptiacus | Genome | 1324.32 | 1324.31 | 1308.81 | 1220.53 | 1204.31 | 1742.72 | 1521.49 | 1325.01 | 1422.13 |