CFLAR

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CFLAR c-FLIP,CASH, FLIP,CASP8AP1,CASH, Casper, CLARP, FLAME, FLIP, I-FLICE, MRIT, c-FLIP CASP8 and FADD-like apoptosis regulator NM_003879 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

This gene was found to be with 3.5 times up-regulation in Ebola-7 h probe and then 0.5 down-regulation in Ebola-23 h for human cells. But no significantly differential expression of this gene was found in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome241 151 297 120 408 236 191 199 269
Read_Max
batR. aegyptiacusTranscriptome 70 52 43 65 52 60 72 75 77
Read_Max
bat_genomeR. aegyptiacusGenome 108 93 68 107 55 52 91 131 141
DESeq
humanH. sapiensGenome 3512.16 3712.32 3615.87 3304.42 3467.42 2849.97 3277.36 3105.68 3065.14
DESeq
batR. aegyptiacusTranscriptome 412.67 346.83 312.49 374.59 365.66 495.02 439.29 394.28 393.74
DESeq
bat_genomeR. aegyptiacusGenome 1324.32 1324.31 1308.81 1220.53 1204.31 1742.72 1521.49 1325.01 1422.13

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3512.16 3304.42 3277.36 -0.09 -0.1 -0.01
7h 3712.32 3467.42 3105.68 -0.1 -0.26 -0.16
23h 3615.87 2849.97 3065.14 -0.34 -0.24 0.11

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3512.16 3712.32 3615.87 0.08 0.04 -0.04
Ebov 3304.42 3467.42 2849.97 0.07 -0.21 -0.28
Marv 3277.36 3105.68 3065.14 -0.08 -0.1 -0.02

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 412.67 374.59 439.29 -0.14 0.09 0.23
7h 346.83 365.66 394.28 0.08 0.18 0.11
23h 312.49 495.02 393.74 0.66 0.33 -0.33

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 412.67 346.83 312.49 -0.25 -0.4 -0.15
Ebov 374.59 365.66 495.02 -0.03 0.4 0.44
Marv 439.29 394.28 393.74 -0.16 -0.16 -0.0