SOS1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| SOS1 | GF1, GGF1, GINGF, HGF, NS4,HGF, GF1 | son of sevenless homolog 1 (Drosophila) | NM_005633 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.
The gene is downregulated in human cells after Marburg infection, but the bat cells homolog is stably expressed.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 208 | 147 | 125 | 199 | 243 | 198 | 281 | 166 | 124 |
Read_Max |  | R. aegyptiacus | Transcriptome | 212 | 162 | 100 | 147 | 128 | 170 | 137 | 170 | 136 |
Read_Max |  | R. aegyptiacus | Genome | 228 | 159 | 85 | 156 | 99 | 94 | 126 | 214 | 137 |
DESeq | | H. sapiens | Genome | 5460.55 | 3290.09 | 2731.27 | 5067.91 | 3658.47 | 4015.88 | 5735.29 | 2823.51 | 3223.9 |
DESeq | | R. aegyptiacus | Transcriptome | 3061.63 | 2559.78 | 2174.11 | 2818.51 | 2609.5 | 3012.63 | 2922.18 | 2776.23 | 2165.9 |
DESeq | | R. aegyptiacus | Genome | 3539.83 | 3058.41 | 2313.01 | 3001.95 | 2847.26 | 3394.07 | 3366.85 | 2960.86 | 2387.92 |