SOS1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SOS1 GF1, GGF1, GINGF, HGF, NS4,HGF, GF1 son of sevenless homolog 1 (Drosophila) NM_005633 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.

The gene is downregulated in human cells after Marburg infection, but the bat cells homolog is stably expressed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome208 147 125 199 243 198 281 166 124
Read_Max
batR. aegyptiacusTranscriptome 212 162 100 147 128 170 137 170 136
Read_Max
bat_genomeR. aegyptiacusGenome 228 159 85 156 99 94 126 214 137
DESeq
humanH. sapiensGenome 5460.55 3290.09 2731.27 5067.91 3658.47 4015.88 5735.29 2823.51 3223.9
DESeq
batR. aegyptiacusTranscriptome 3061.63 2559.78 2174.11 2818.51 2609.5 3012.63 2922.18 2776.23 2165.9
DESeq
bat_genomeR. aegyptiacusGenome 3539.83 3058.41 2313.01 3001.95 2847.26 3394.07 3366.85 2960.86 2387.92

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5460.55 5067.91 5735.29 -0.11 0.07 0.18
7h 3290.09 3658.47 2823.51 0.15 -0.22 -0.37
23h 2731.27 4015.88 3223.9 0.56 0.24 -0.32

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5460.55 3290.09 2731.27 -0.73 -1.0 -0.27
Ebov 5067.91 3658.47 4015.88 -0.47 -0.34 0.13
Marv 5735.29 2823.51 3223.9 -1.02 -0.83 0.19

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3061.63 2818.51 2922.18 -0.12 -0.07 0.05
7h 2559.78 2609.5 2776.23 0.03 0.12 0.09
23h 2174.11 3012.63 2165.9 0.47 -0.01 -0.48

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3061.63 2559.78 2174.11 -0.26 -0.49 -0.24
Ebov 2818.51 2609.5 3012.63 -0.11 0.1 0.21
Marv 2922.18 2776.23 2165.9 -0.07 -0.43 -0.36