FGFR4

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FGFR4 FGFR4, CD334, JTK2, TKF,JTK2 fibroblast growth factor receptor 4 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

The gene is slightly increased upon human cells Ebola infection. The bat cells homolog is almost not expressed. In human cells Marburg infected cells after 7 h one exon is disproportionally highly expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome591 798 879 746 1104 1349 799 1166 854
Read_Max
batR. aegyptiacusTranscriptome 2 2 4 6 2 2 3 2 4
Read_Max
bat_genomeR. aegyptiacusGenome 5 3 4 2 2 2 2 5 6
DESeq
humanH. sapiensGenome 9564.35 11788.69 10585.5 11228.74 10805.12 16797.43 11536.24 12319.79 9030.33
DESeq
batR. aegyptiacusTranscriptome 5.2 6.45 8.33 8.33 3.19 6.13 8.79 4.3 4.5
DESeq
bat_genomeR. aegyptiacusGenome 13.75 10.95 44.63 9.87 6.7 7.83 12.37 17.44 33.39

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 9564.35 11228.74 11536.24 0.23 0.27 0.04
7h 11788.69 10805.12 12319.79 -0.13 0.06 0.19
23h 10585.5 16797.43 9030.33 0.67 -0.23 -0.9

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 9564.35 11788.69 10585.5 0.3 0.15 -0.16
Ebov 11228.74 10805.12 16797.43 -0.06 0.58 0.64
Marv 11536.24 12319.79 9030.33 0.09 -0.35 -0.45

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5.2 8.33 8.79 0.68 0.76 0.08
7h 6.45 3.19 4.3 -1.02 -0.58 0.43
23h 8.33 6.13 4.5 -0.44 -0.89 -0.45

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5.2 6.45 8.33 0.31 0.68 0.37
Ebov 8.33 3.19 6.13 -1.38 -0.44 0.94
Marv 8.79 4.3 4.5 -1.03 -0.97 0.07