MAPKAPK5
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| MAPKAPK5 | MK5, PRAK,PRAK | mitogen-activated protein kinase-activated protein kinase 5 | NM_139078 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites.
The gene is slightly upregulated in human cells Ebola infected cells after 7 h. Homolog in bat cells is expressed relatively stably.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 303 | 222 | 219 | 219 | 340 | 247 | 295 | 260 | 179 |
Read_Max |  | R. aegyptiacus | Transcriptome | 183 | 114 | 96 | 128 | 104 | 108 | 121 | 148 | 120 |
Read_Max |  | R. aegyptiacus | Genome | 287 | 216 | 143 | 205 | 149 | 117 | 186 | 334 | 243 |
DESeq | | H. sapiens | Genome | 2349.22 | 1903.06 | 2024.38 | 2202.52 | 2206.54 | 2470.99 | 2285.24 | 1974.6 | 1987.58 |
DESeq | | R. aegyptiacus | Transcriptome | 1028.49 | 818.83 | 879.28 | 973.44 | 903.35 | 765.78 | 944.32 | 1015.58 | 730.51 |
DESeq | | R. aegyptiacus | Genome | 2813.64 | 2828.41 | 2313.01 | 2567.46 | 2725.6 | 2349.74 | 2752.85 | 3002.09 | 2014.62 |