TNFRSF1A

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TNFRSF1A	CD120a, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR60,TNF-R, CD120a	tumor necrosis factor receptor superfamily, member 1A	NM_001065	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

It is slightly downregulated in human cells 23 h after Ebola virus infection. In bat cells it is constantly expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	118	171	144	158	235	93	208	282	159
Read_Max	R. aegyptiacus	Transcriptome	110	116	121	110	106	176	74	129	196
Read_Max	R. aegyptiacus	Genome	141	137	117	123	108	120	64	180	269
DESeq	H. sapiens	Genome	1265.42	1566.5	1166.58	1429.14	1481.38	736.6	1632.6	1908.25	1586.35
DESeq	R. aegyptiacus	Transcriptome	643.71	715.35	994.11	753.68	706.24	980.07	599.47	747.89	1067.27
DESeq	R. aegyptiacus	Genome	1056.19	1187.4	1547.58	1300.52	1233.33	1493.39	997.46	1145.81	1643.03

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1265.42	1429.14	1632.6	0.18	0.37	0.19
7h	1566.5	1481.38	1908.25	-0.08	0.28	0.37
23h	1166.58	736.6	1586.35	-0.66	0.44	1.11

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1265.42	1566.5	1166.58	0.31	-0.12	-0.43
Ebov	1429.14	1481.38	736.6	0.05	-0.96	-1.01
Marv	1632.6	1908.25	1586.35	0.23	-0.04	-0.27

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	643.71	753.68	599.47	0.23	-0.1	-0.33
7h	715.35	706.24	747.89	-0.02	0.06	0.08
23h	994.11	980.07	1067.27	-0.02	0.1	0.12

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	643.71	715.35	994.11	0.15	0.63	0.47
Ebov	753.68	706.24	980.07	-0.09	0.38	0.47
Marv	599.47	747.89	1067.27	0.32	0.83	0.51

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material