VCL

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
VCL CMD1W, CMH15, HEL114, MV, MVCL vinculin NM_003373, NM_014000 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

The gene is uniformly expressed in human cells, as is the bat cells homolog.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome238 264 268 256 343 297 342 420 327
Read_Max
batR. aegyptiacusTranscriptome 813 641 608 681 623 744 447 871 813
Read_Max
bat_genomeR. aegyptiacusGenome 890 719 528 626 530 430 389 1073 905
DESeq
humanH. sapiensGenome 5926.34 6131.46 5281.83 6321.53 5660.76 7226.73 6801.09 7335.04 6856.72
DESeq
batR. aegyptiacusTranscriptome 10879.14 10234.29 11336.86 10178.65 10339.74 10893.93 8320.69 10570.69 11072.19
DESeq
bat_genomeR. aegyptiacusGenome 14427.44 13156.35 13531.04 14022.27 13614.6 14636.26 11916.67 13453.91 14477.35

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5926.34 6321.53 6801.09 0.09 0.2 0.11
7h 6131.46 5660.76 7335.04 -0.12 0.26 0.37
23h 5281.83 7226.73 6856.72 0.45 0.38 -0.08

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5926.34 6131.46 5281.83 0.05 -0.17 -0.22
Ebov 6321.53 5660.76 7226.73 -0.16 0.19 0.35
Marv 6801.09 7335.04 6856.72 0.11 0.01 -0.1

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10879.14 10178.65 8320.69 -0.1 -0.39 -0.29
7h 10234.29 10339.74 10570.69 0.01 0.05 0.03
23h 11336.86 10893.93 11072.19 -0.06 -0.03 0.02

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10879.14 10234.29 11336.86 -0.09 0.06 0.15
Ebov 10178.65 10339.74 10893.93 0.02 0.1 0.08
Marv 8320.69 10570.69 11072.19 0.35 0.41 0.07