BAX
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| BAX | BCL2L4 | BCL2-associated X protein | NM_138763 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.
An up-regulation of this gene was found for 23 h Marbug probe in bat cells, but not in human cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 129 | 128 | 85 | 121 | 187 | 115 | 148 | 204 | 114 |
Read_Max |  | R. aegyptiacus | Transcriptome | 83 | 88 | 87 | 85 | 63 | 72 | 39 | 68 | 135 |
Read_Max |  | R. aegyptiacus | Genome | 100 | 93 | 90 | 86 | 62 | 47 | 41 | 103 | 160 |
DESeq | | H. sapiens | Genome | 865.6 | 771.0 | 609.6 | 736.74 | 720.46 | 637.91 | 841.36 | 809.14 | 726.26 |
DESeq | | R. aegyptiacus | Transcriptome | 137.1 | 185.26 | 219.66 | 153.0 | 131.32 | 142.15 | 96.67 | 130.71 | 228.42 |
DESeq | | R. aegyptiacus | Genome | 323.99 | 337.69 | 665.0 | 417.71 | 348.23 | 361.6 | 258.64 | 382.2 | 482.89 |