VEGFA

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
VEGFA VEGF, VEGF-A, VPF,VEGF-A vascular endothelial growth factor A NM_001025366 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

It is constantly expressed in human cells but upregulated after 7 h and 23 h in all bat cells probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome120 225 216 189 235 379 190 260 165
Read_Max
batR. aegyptiacusTranscriptome 172 191 252 223 196 554 119 279 542
Read_Max
bat_genomeR. aegyptiacusGenome 305 382 481 252 280 535 163 569 1018
DESeq
humanH. sapiensGenome 2182.79 3723.54 3741.96 2870.96 3169.07 6435.86 2861.56 3917.02 3756.7
DESeq
batR. aegyptiacusTranscriptome 620.18 710.81 1420.43 993.58 935.11 2154.18 645.08 1042.02 1900.87
DESeq
bat_genomeR. aegyptiacusGenome 3284.59 4988.74 6987.0 3610.24 4691.11 9887.18 3065.47 5001.11 8996.86

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2182.79 2870.96 2861.56 0.4 0.39 -0.0
7h 3723.54 3169.07 3917.02 -0.23 0.07 0.31
23h 3741.96 6435.86 3756.7 0.78 0.01 -0.78

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2182.79 3723.54 3741.96 0.77 0.78 0.01
Ebov 2870.96 3169.07 6435.86 0.14 1.16 1.02
Marv 2861.56 3917.02 3756.7 0.45 0.39 -0.06

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 620.18 993.58 645.08 0.68 0.06 -0.62
7h 710.81 935.11 1042.02 0.4 0.55 0.16
23h 1420.43 2154.18 1900.87 0.6 0.42 -0.18

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 620.18 710.81 1420.43 0.2 1.2 1.0
Ebov 993.58 935.11 2154.18 -0.09 1.12 1.2
Marv 645.08 1042.02 1900.87 0.69 1.56 0.87