VEGFA

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
VEGFA	VEGF, VEGF-A, VPF,VEGF-A	vascular endothelial growth factor A	NM_001025366	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

It is constantly expressed in human cells but upregulated after 7 h and 23 h in all bat cells probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	120	225	216	189	235	379	190	260	165
Read_Max	R. aegyptiacus	Transcriptome	172	191	252	223	196	554	119	279	542
Read_Max	R. aegyptiacus	Genome	305	382	481	252	280	535	163	569	1018
DESeq	H. sapiens	Genome	2182.79	3723.54	3741.96	2870.96	3169.07	6435.86	2861.56	3917.02	3756.7
DESeq	R. aegyptiacus	Transcriptome	620.18	710.81	1420.43	993.58	935.11	2154.18	645.08	1042.02	1900.87
DESeq	R. aegyptiacus	Genome	3284.59	4988.74	6987.0	3610.24	4691.11	9887.18	3065.47	5001.11	8996.86

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2182.79	2870.96	2861.56	0.4	0.39	-0.0
7h	3723.54	3169.07	3917.02	-0.23	0.07	0.31
23h	3741.96	6435.86	3756.7	0.78	0.01	-0.78

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2182.79	3723.54	3741.96	0.77	0.78	0.01
Ebov	2870.96	3169.07	6435.86	0.14	1.16	1.02
Marv	2861.56	3917.02	3756.7	0.45	0.39	-0.06

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	620.18	993.58	645.08	0.68	0.06	-0.62
7h	710.81	935.11	1042.02	0.4	0.55	0.16
23h	1420.43	2154.18	1900.87	0.6	0.42	-0.18

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	620.18	710.81	1420.43	0.2	1.2	1.0
Ebov	993.58	935.11	2154.18	-0.09	1.12	1.2
Marv	645.08	1042.02	1900.87	0.69	1.56	0.87

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material