PAK1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PAK1	AK295344, B7Z302, B7Z302_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 1	NM_002576	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), transcript variant 2 gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

This gene is slightly expressed in human cells and even more less in bat cells, but from the sequencing results a small upregulation during Ebola and Marburg infection in human cells and bat cells can be observed. On the first 9 (5'-3') of 14 annotated introns, some reads could be mapped.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	49	64	50	50	91	149	62	82	79
Read_Max	R. aegyptiacus	Transcriptome	17	13	9	15	27	15	15	27	22
Read_Max	R. aegyptiacus	Genome	20	14	8	12	17	11	14	26	27
DESeq	H. sapiens	Genome	658.58	723.07	886.6	716.21	761.92	1769.6	765.05	819.53	1518.94
DESeq	R. aegyptiacus	Transcriptome	106.86	84.51	82.84	105.39	144.46	80.56	123.36	115.02	119.09
DESeq	R. aegyptiacus	Genome	158.99	130.51	122.74	135.29	213.18	117.49	167.56	134.8	160.96

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	658.58	716.21	765.05	0.12	0.22	0.1
7h	723.07	761.92	819.53	0.08	0.18	0.11
23h	886.6	1769.6	1518.94	1.0	0.78	-0.22

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	658.58	723.07	886.6	0.13	0.43	0.29
Ebov	716.21	761.92	1769.6	0.09	1.3	1.22
Marv	765.05	819.53	1518.94	0.1	0.99	0.89

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	106.86	105.39	123.36	-0.02	0.21	0.23
7h	84.51	144.46	115.02	0.77	0.44	-0.33
23h	82.84	80.56	119.09	-0.04	0.52	0.56

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	106.86	84.51	82.84	-0.34	-0.37	-0.03
Ebov	105.39	144.46	80.56	0.45	-0.39	-0.84
Marv	123.36	115.02	119.09	-0.1	-0.05	0.05

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material