PAK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PAK1 AK295344, B7Z302, B7Z302_HUMAN p21 protein (Cdc42/Rac)-activated kinase 1 NM_002576 pdf

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Description

Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), transcript variant 2 gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

This gene is slightly expressed in human cells and even more less in bat cells, but from the sequencing results a small upregulation during Ebola and Marburg infection in human cells and bat cells can be observed. On the first 9 (5'-3') of 14 annotated introns, some reads could be mapped.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome49 64 50 50 91 149 62 82 79
Read_Max
batR. aegyptiacusTranscriptome 17 13 9 15 27 15 15 27 22
Read_Max
bat_genomeR. aegyptiacusGenome 20 14 8 12 17 11 14 26 27
DESeq
humanH. sapiensGenome 658.58 723.07 886.6 716.21 761.92 1769.6 765.05 819.53 1518.94
DESeq
batR. aegyptiacusTranscriptome 106.86 84.51 82.84 105.39 144.46 80.56 123.36 115.02 119.09
DESeq
bat_genomeR. aegyptiacusGenome 158.99 130.51 122.74 135.29 213.18 117.49 167.56 134.8 160.96

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 658.58 716.21 765.05 0.12 0.22 0.1
7h 723.07 761.92 819.53 0.08 0.18 0.11
23h 886.6 1769.6 1518.94 1.0 0.78 -0.22

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 658.58 723.07 886.6 0.13 0.43 0.29
Ebov 716.21 761.92 1769.6 0.09 1.3 1.22
Marv 765.05 819.53 1518.94 0.1 0.99 0.89

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 106.86 105.39 123.36 -0.02 0.21 0.23
7h 84.51 144.46 115.02 0.77 0.44 -0.33
23h 82.84 80.56 119.09 -0.04 0.52 0.56

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 106.86 84.51 82.84 -0.34 -0.37 -0.03
Ebov 105.39 144.46 80.56 0.45 -0.39 -0.84
Marv 123.36 115.02 119.09 -0.1 -0.05 0.05