MAP3K12

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAP3K12 DLK, MEKK12, MUK, ZPK, ZPKP1,MUK, DLK mitogen-activated protein kinase kinase kinase 12 NM_006301 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

It is downregulated after 23 h in all human cells probes and seems not to be expressed in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome300 136 102 124 143 115 160 149 73
Read_Max
batR. aegyptiacusTranscriptome 18 16 22 23 17 22 13 24 23
Read_Max
bat_genomeR. aegyptiacusGenome 128 65 48 85 49 32 83 103 67
DESeq
humanH. sapiensGenome 1148.72 610.88 520.25 647.77 556.25 780.03 633.46 592.52 456.6
DESeq
batR. aegyptiacusTranscriptome 139.62 106.29 189.12 204.28 143.36 152.42 113.35 169.55 201.31
DESeq
bat_genomeR. aegyptiacusGenome 876.58 994.83 961.8 881.82 863.89 832.85 822.03 1072.06 984.62

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1148.72 647.77 633.46 -0.83 -0.86 -0.03
7h 610.88 556.25 592.52 -0.14 -0.04 0.09
23h 520.25 780.03 456.6 0.58 -0.19 -0.77

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1148.72 610.88 520.25 -0.91 -1.14 -0.23
Ebov 647.77 556.25 780.03 -0.22 0.27 0.49
Marv 633.46 592.52 456.6 -0.1 -0.47 -0.38

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 139.62 204.28 113.35 0.55 -0.3 -0.85
7h 106.29 143.36 169.55 0.43 0.67 0.24
23h 189.12 152.42 201.31 -0.31 0.09 0.4

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 139.62 106.29 189.12 -0.39 0.44 0.83
Ebov 204.28 143.36 152.42 -0.51 -0.42 0.09
Marv 113.35 169.55 201.31 0.58 0.83 0.25