MAP4K3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAP4K3	GLK, MEKKK3, MEKKK 3, MAPKKKK3, RAB8IPL1	mitogen-activated protein kinase kinase kinase kinase 3	NM_003618	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

MAP4K3 is expressed in both human cells and bat cells and is very slightly down-regulated in Ebola-infected cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	128	152	156	116	179	136	165	149	151
Read_Max	R. aegyptiacus	Transcriptome	262	242	148	213	168	175	204	196	213
Read_Max	R. aegyptiacus	Genome	362	313	168	296	204	119	227	349	257
DESeq	H. sapiens	Genome	2024.48	2089.7	2422.5	2070.2	2301.65	1831.45	1931.73	1854.69	2099.58
DESeq	R. aegyptiacus	Transcriptome	2166.04	2131.35	1632.97	2063.09	2077.29	1755.11	2476.1	1964.07	1711.06
DESeq	R. aegyptiacus	Genome	4583.13	4643.74	3784.72	4384.43	4635.3	3717.81	5082.88	4486.49	3579.74

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2024.48	2070.2	1931.73	0.03	-0.07	-0.1
7h	2089.7	2301.65	1854.69	0.14	-0.17	-0.31
23h	2422.5	1831.45	2099.58	-0.4	-0.21	0.2

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2024.48	2089.7	2422.5	0.05	0.26	0.21
Ebov	2070.2	2301.65	1831.45	0.15	-0.18	-0.33
Marv	1931.73	1854.69	2099.58	-0.06	0.12	0.18

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2166.04	2063.09	2476.1	-0.07	0.19	0.26
7h	2131.35	2077.29	1964.07	-0.04	-0.12	-0.08
23h	1632.97	1755.11	1711.06	0.1	0.07	-0.04

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2166.04	2131.35	1632.97	-0.02	-0.41	-0.38
Ebov	2063.09	2077.29	1755.11	0.01	-0.23	-0.24
Marv	2476.1	1964.07	1711.06	-0.33	-0.53	-0.2

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material