ATM

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ATM	AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1,TEL1	ATM serine/threonine kinase	NM_000051	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The ATM serine/threonine kinase (EC:2.7.11.1) gene is involved in the NF-kappa B, FoxO and p53 signaling pathways, Cell cycle, Apoptosis, HTLV-I infection, transcriptional misregulation in cancer, MicroRNAs in cancer.

It did not present a particularly interesting differential expression pattern in the samples analyzed

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	86	86	121	72	149	128	75	80	107
Read_Max	R. aegyptiacus	Transcriptome	164	111	95	135	124	155	132	146	125
Read_Max	R. aegyptiacus	Genome	180	153	84	109	108	99	121	189	146
DESeq	H. sapiens	Genome	3820.66	3698.04	5325.52	3112.78	4299.88	4563.3	2950.16	3024.94	4947.34
DESeq	R. aegyptiacus	Transcriptome	5070.41	3658.99	3554.45	5555.44	5493.97	5118.33	4871.11	4946.68	3826.98
DESeq	R. aegyptiacus	Genome	6295.89	6934.58	4149.58	4850.52	6828.51	6477.44	6201.79	5963.75	4771.56

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3820.66	3112.78	2950.16	-0.3	-0.37	-0.08
7h	3698.04	4299.88	3024.94	0.22	-0.29	-0.51
23h	5325.52	4563.3	4947.34	-0.22	-0.11	0.12

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3820.66	3698.04	5325.52	-0.05	0.48	0.53
Ebov	3112.78	4299.88	4563.3	0.47	0.55	0.09
Marv	2950.16	3024.94	4947.34	0.04	0.75	0.71

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5070.41	5555.44	4871.11	0.13	-0.06	-0.19
7h	3658.99	5493.97	4946.68	0.59	0.44	-0.15
23h	3554.45	5118.33	3826.98	0.53	0.11	-0.42

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5070.41	3658.99	3554.45	-0.47	-0.51	-0.04
Ebov	5555.44	5493.97	5118.33	-0.02	-0.12	-0.1
Marv	4871.11	4946.68	3826.98	0.02	-0.35	-0.37

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

ATM