FLT1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
FLT1	FLT1, FLT, FLT-1, VEGFR-1, VEGFR1,VEGFR1	fms-related tyrosine kinase 1	NM_002019	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes.

FLT1 is not expressed in human cells on no homolog was found in bat cells transcript assemblies. %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

\ucscfigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.01116/snapshots//hg19.goi.01116_ucsc.eps % \caption\ucsc of gene FLT1. % <- say something about the figure here \endfigure }

\setcounterfigure0 \enddocument

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	3	2	3	4	3	3	4	2	1
Read_Max	R. aegyptiacus	Transcriptome	590	533	236	371	295	343	333	393	395
Read_Max	R. aegyptiacus	Genome	710	383	201	558	243	212	318	475	437
DESeq	H. sapiens	Genome	4.04	7.12	16.89	13.55	12.38	7.58	10.65	8.99	2.09
DESeq	R. aegyptiacus	Transcriptome	7300.14	7099.13	4289.82	5059.15	5172.01	6269.34	6118.12	4671.56	5217.76
DESeq	R. aegyptiacus	Genome	13491.56	8475.19	7094.11	13635.17	8781.74	9577.79	11922.29	7859.68	8306.77

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4.04	13.55	10.65	1.75	1.4	-0.35
7h	7.12	12.38	8.99	0.8	0.34	-0.46
23h	16.89	7.58	2.09	-1.16	-3.01	-1.86

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4.04	7.12	16.89	0.82	2.06	1.25
Ebov	13.55	12.38	7.58	-0.13	-0.84	-0.71
Marv	10.65	8.99	2.09	-0.24	-2.35	-2.1

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7300.14	5059.15	6118.12	-0.53	-0.25	0.27
7h	7099.13	5172.01	4671.56	-0.46	-0.6	-0.15
23h	4289.82	6269.34	5217.76	0.55	0.28	-0.26

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7300.14	7099.13	4289.82	-0.04	-0.77	-0.73
Ebov	5059.15	5172.01	6269.34	0.03	0.31	0.28
Marv	6118.12	4671.56	5217.76	-0.39	-0.23	0.16

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material