ITGAV

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ITGAV VNRA, MSK8, VTNR,CD51 integrin, alpha V NM_002210 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens integrin, alpha V (ITGAV), transcript variant 3, mRNA. This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome591 474 357 670 720 533 712 678 714
Read_Max
batR. aegyptiacusTranscriptome 1183 910 630 997 748 682 909 1027 718
Read_Max
bat_genomeR. aegyptiacusGenome 1387 1007 517 934 609 389 750 1327 857
DESeq
humanH. sapiensGenome 15327.33 12616.83 9193.56 15160.68 14854.42 13332.61 15353.84 11968.08 19970.13
DESeq
batR. aegyptiacusTranscriptome 17580.94 14453.24 12209.04 17376.72 15394.68 11430.3 18158.8 16009.62 10707.44
DESeq
bat_genomeR. aegyptiacusGenome 21823.35 21013.66 13856.84 19260.87 19214.24 14201.55 22390.56 18901.45 12977.3

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 15327.33 15160.68 15353.84 -0.02 0.0 0.02
7h 12616.83 14854.42 11968.08 0.24 -0.08 -0.31
23h 9193.56 13332.61 19970.13 0.54 1.12 0.58

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 15327.33 12616.83 9193.56 -0.28 -0.74 -0.46
Ebov 15160.68 14854.42 13332.61 -0.03 -0.19 -0.16
Marv 15353.84 11968.08 19970.13 -0.36 0.38 0.74

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 17580.94 17376.72 18158.8 -0.02 0.05 0.06
7h 14453.24 15394.68 16009.62 0.09 0.15 0.06
23h 12209.04 11430.3 10707.44 -0.1 -0.19 -0.09

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 17580.94 14453.24 12209.04 -0.28 -0.53 -0.24
Ebov 17376.72 15394.68 11430.3 -0.17 -0.6 -0.43
Marv 18158.8 16009.62 10707.44 -0.18 -0.76 -0.58