ITGAV

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ITGAV	VNRA, MSK8, VTNR,CD51	integrin, alpha V	NM_002210	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens integrin, alpha V (ITGAV), transcript variant 3, mRNA. This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	591	474	357	670	720	533	712	678	714
Read_Max	R. aegyptiacus	Transcriptome	1183	910	630	997	748	682	909	1027	718
Read_Max	R. aegyptiacus	Genome	1387	1007	517	934	609	389	750	1327	857
DESeq	H. sapiens	Genome	15327.33	12616.83	9193.56	15160.68	14854.42	13332.61	15353.84	11968.08	19970.13
DESeq	R. aegyptiacus	Transcriptome	17580.94	14453.24	12209.04	17376.72	15394.68	11430.3	18158.8	16009.62	10707.44
DESeq	R. aegyptiacus	Genome	21823.35	21013.66	13856.84	19260.87	19214.24	14201.55	22390.56	18901.45	12977.3

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	15327.33	15160.68	15353.84	-0.02	0.0	0.02
7h	12616.83	14854.42	11968.08	0.24	-0.08	-0.31
23h	9193.56	13332.61	19970.13	0.54	1.12	0.58

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	15327.33	12616.83	9193.56	-0.28	-0.74	-0.46
Ebov	15160.68	14854.42	13332.61	-0.03	-0.19	-0.16
Marv	15353.84	11968.08	19970.13	-0.36	0.38	0.74

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	17580.94	17376.72	18158.8	-0.02	0.05	0.06
7h	14453.24	15394.68	16009.62	0.09	0.15	0.06
23h	12209.04	11430.3	10707.44	-0.1	-0.19	-0.09

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	17580.94	14453.24	12209.04	-0.28	-0.53	-0.24
Ebov	17376.72	15394.68	11430.3	-0.17	-0.6	-0.43
Marv	18158.8	16009.62	10707.44	-0.18	-0.76	-0.58

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material