KITLG

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
KITLG SCF, SF, Kitl, KL-1, FPH2 KIT ligand NM_003994 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.

The gene KITLG is expressed throughout human cells and bat cells datasets. Interestingly expression patterns in human cells and bat cells are directly inverted, while in human cells expression during infection goes down, it goes down in bat cells wild type while it remains stable in bat cells infection datasets.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome117 112 105 109 144 60 114 124 77
Read_Max
batR. aegyptiacusTranscriptome 247 174 116 256 191 187 170 218 187
Read_Max
bat_genomeR. aegyptiacusGenome 289 257 98 212 168 153 171 353 264
DESeq
humanH. sapiensGenome 1904.74 1967.31 1823.83 1766.78 1781.36 876.09 1699.27 1598.9 1679.86
DESeq
batR. aegyptiacusTranscriptome 1135.19 965.87 797.44 1239.9 1419.14 1255.95 1144.55 1241.14 1021.79
DESeq
bat_genomeR. aegyptiacusGenome 3877.57 4207.48 2386.65 3580.62 4664.32 4356.15 4351.94 4338.21 3685.05

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1904.74 1766.78 1699.27 -0.11 -0.16 -0.06
7h 1967.31 1781.36 1598.9 -0.14 -0.3 -0.16
23h 1823.83 876.09 1679.86 -1.06 -0.12 0.94

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1904.74 1967.31 1823.83 0.05 -0.06 -0.11
Ebov 1766.78 1781.36 876.09 0.01 -1.01 -1.02
Marv 1699.27 1598.9 1679.86 -0.09 -0.02 0.07

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1135.19 1239.9 1144.55 0.13 0.01 -0.12
7h 965.87 1419.14 1241.14 0.56 0.36 -0.19
23h 797.44 1255.95 1021.79 0.66 0.36 -0.3

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1135.19 965.87 797.44 -0.23 -0.51 -0.28
Ebov 1239.9 1419.14 1255.95 0.19 0.02 -0.18
Marv 1144.55 1241.14 1021.79 0.12 -0.16 -0.28