Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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FN1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
FN1	BX641150, Q59G22, Q59G22_HUMAN,MSF, CIG, LETS, GFND2, FINC	fibronectin 1	NM_212476	pdf		NONE

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Description

Homo sapiens fibronectin 1 (FN1), transcript variant 3 gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.

This among different species well conserved and extremely high expressed gene in human cells and bat cells is able to form lots of isoforms du to a large set of exons and introns. Between the human cells samples no big difference in expression regulation could be observed: till 7 h the gene is upregulated and afterwards downregulated, except the Ebola 23 h sample, which shows an equal amount of transcripts. In bat cells on the other hand, the Ebola samples show a downregulation between 3 h and 7 h and upregulation subsequently, while during Marburg infection the transcripts rise 2 fold and decreased till the 23 h sample. The bat cells samples without any infection show a downregulation to a constant level after 7 h only.

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