HGF
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| HGF | DFNB39, F-TCF, HGFB, HPTA, SF,SF | hepatocyte growth factor (hepapoietin A; scatter factor) | NM_000601 |  |
NONE | NONE | NONE |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
No expression in human cells and bat cells homolog found.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 4 | 2 | 3 | 2 | 2 | 3 | 2 | 1 | 1 |
Read_Max |  | R. aegyptiacus | Transcriptome | 2 | 5 | 5 | 8 | 2 | 2 | 4 | 3 | 2 |
Read_Max |  | R. aegyptiacus | Genome | 3 | 5 | 5 | 4 | 3 | 2 | 4 | 6 | 4 |
DESeq | | H. sapiens | Genome | 8.1 | 5.08 | 7.95 | 10.13 | 6.69 | 3.63 | 7.14 | 1.0 | 1.0 |
DESeq | | R. aegyptiacus | Transcriptome | 4.36 | 17.34 | 29.1 | 22.98 | 10.86 | 9.98 | 12.12 | 9.26 | 4.5 |
DESeq | | R. aegyptiacus | Genome | 15.47 | 38.33 | 58.02 | 29.62 | 26.79 | 13.05 | 39.36 | 31.72 | 10.27 |