HGF

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HGF DFNB39, F-TCF, HGFB, HPTA, SF,SF hepatocyte growth factor (hepapoietin A; scatter factor) NM_000601 pdf NONE NONE NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

No expression in human cells and bat cells homolog found.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome4 2 3 2 2 3 2 1 1
Read_Max
batR. aegyptiacusTranscriptome 2 5 5 8 2 2 4 3 2
Read_Max
bat_genomeR. aegyptiacusGenome 3 5 5 4 3 2 4 6 4
DESeq
humanH. sapiensGenome 8.1 5.08 7.95 10.13 6.69 3.63 7.14 1.0 1.0
DESeq
batR. aegyptiacusTranscriptome 4.36 17.34 29.1 22.98 10.86 9.98 12.12 9.26 4.5
DESeq
bat_genomeR. aegyptiacusGenome 15.47 38.33 58.02 29.62 26.79 13.05 39.36 31.72 10.27

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8.1 10.13 7.14 0.32 -0.18 -0.5
7h 5.08 6.69 1.0 0.4 -2.34 -2.74
23h 7.95 3.63 1.0 -1.13 -2.99 -1.86

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8.1 5.08 7.95 -0.67 -0.03 0.65
Ebov 10.13 6.69 3.63 -0.6 -1.48 -0.88
Marv 7.14 1.0 1.0 -2.84 -2.84 0.0

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4.36 22.98 12.12 2.4 1.47 -0.92
7h 17.34 10.86 9.26 -0.68 -0.91 -0.23
23h 29.1 9.98 4.5 -1.54 -2.69 -1.15

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4.36 17.34 29.1 1.99 2.74 0.75
Ebov 22.98 10.86 9.98 -1.08 -1.2 -0.12
Marv 12.12 9.26 4.5 -0.39 -1.43 -1.04