MAP3K2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAP3K2 MEKK2, MEKK2B,MEKK2B mitogen-activated protein kinase kinase kinase 2 NM_006609 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.

The gene is uniformly expressed in human cells. The bat cells homolog shows variation in Ebola infected probes, going up after 7 h and down again after 23 h.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome215 134 130 190 153 205 174 141 131
Read_Max
batR. aegyptiacusTranscriptome 110 70 55 86 59 88 77 93 80
Read_Max
bat_genomeR. aegyptiacusGenome 118 81 48 71 52 57 66 115 91
DESeq
humanH. sapiensGenome 6045.07 4024.4 4714.93 5062.21 4279.56 5484.45 4625.62 3126.46 5208.3
DESeq
batR. aegyptiacusTranscriptome 953.72 748.03 670.4 924.91 810.27 1045.51 958.78 848.69 731.38
DESeq
bat_genomeR. aegyptiacusGenome 2909.04 2743.53 1936.99 2287.01 2522.46 3599.02 2993.5 2485.09 2202.13

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6045.07 5062.21 4625.62 -0.26 -0.39 -0.13
7h 4024.4 4279.56 3126.46 0.09 -0.36 -0.45
23h 4714.93 5484.45 5208.3 0.22 0.14 -0.07

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6045.07 4024.4 4714.93 -0.59 -0.36 0.23
Ebov 5062.21 4279.56 5484.45 -0.24 0.12 0.36
Marv 4625.62 3126.46 5208.3 -0.57 0.17 0.74

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 953.72 924.91 958.78 -0.04 0.01 0.05
7h 748.03 810.27 848.69 0.12 0.18 0.07
23h 670.4 1045.51 731.38 0.64 0.13 -0.52

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 953.72 748.03 670.4 -0.35 -0.51 -0.16
Ebov 924.91 810.27 1045.51 -0.19 0.18 0.37
Marv 958.78 848.69 731.38 -0.18 -0.39 -0.21