CRK

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CRK proto-oncogene C-crk v-crk avian sarcoma virus CT10 oncogene homolog NM_016823 pdf

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Description

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.

The gene is uniformly expressed in human cells. The bat cells homolog is also uniformly expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome303 259 300 290 401 387 278 364 268
Read_Max
batR. aegyptiacusTranscriptome 614 614 428 550 494 695 542 598 663
Read_Max
bat_genomeR. aegyptiacusGenome 756 595 376 612 462 418 493 791 725
DESeq
humanH. sapiensGenome 3535.5 2855.62 3106.56 3273.62 3337.35 4121.15 3082.62 2749.17 3315.23
DESeq
batR. aegyptiacusTranscriptome 2244.17 2263.87 2006.76 2126.27 2236.08 2979.26 2619.6 1966.55 2269.99
DESeq
bat_genomeR. aegyptiacusGenome 8165.92 8121.07 6136.78 7511.79 8751.61 11672.98 10224.25 7900.91 7389.79

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3535.5 3273.62 3082.62 -0.11 -0.2 -0.09
7h 2855.62 3337.35 2749.17 0.22 -0.05 -0.28
23h 3106.56 4121.15 3315.23 0.41 0.09 -0.31

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3535.5 2855.62 3106.56 -0.31 -0.19 0.12
Ebov 3273.62 3337.35 4121.15 0.03 0.33 0.3
Marv 3082.62 2749.17 3315.23 -0.17 0.1 0.27

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2244.17 2126.27 2619.6 -0.08 0.22 0.3
7h 2263.87 2236.08 1966.55 -0.02 -0.2 -0.19
23h 2006.76 2979.26 2269.99 0.57 0.18 -0.39

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2244.17 2263.87 2006.76 0.01 -0.16 -0.17
Ebov 2126.27 2236.08 2979.26 0.07 0.49 0.41
Marv 2619.6 1966.55 2269.99 -0.41 -0.21 0.21