CRK
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| CRK | proto-oncogene C-crk | v-crk avian sarcoma virus CT10 oncogene homolog | NM_016823 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.
The gene is uniformly expressed in human cells. The bat cells homolog is also uniformly expressed.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 303 | 259 | 300 | 290 | 401 | 387 | 278 | 364 | 268 |
Read_Max |  | R. aegyptiacus | Transcriptome | 614 | 614 | 428 | 550 | 494 | 695 | 542 | 598 | 663 |
Read_Max |  | R. aegyptiacus | Genome | 756 | 595 | 376 | 612 | 462 | 418 | 493 | 791 | 725 |
DESeq | | H. sapiens | Genome | 3535.5 | 2855.62 | 3106.56 | 3273.62 | 3337.35 | 4121.15 | 3082.62 | 2749.17 | 3315.23 |
DESeq | | R. aegyptiacus | Transcriptome | 2244.17 | 2263.87 | 2006.76 | 2126.27 | 2236.08 | 2979.26 | 2619.6 | 1966.55 | 2269.99 |
DESeq | | R. aegyptiacus | Genome | 8165.92 | 8121.07 | 6136.78 | 7511.79 | 8751.61 | 11672.98 | 10224.25 | 7900.91 | 7389.79 |