HIF1A

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
HIF1A	MOP1, HIF-1alpha, PASD8, HIF1, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	NM_001530	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

The gene is constantly expressed in human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	881	765	755	743	894	1105	948	816	680
Read_Max	R. aegyptiacus	Transcriptome	795	700	409	733	578	579	577	962	566
Read_Max	R. aegyptiacus	Genome	538	503	246	508	322	229	365	670	459
DESeq	H. sapiens	Genome	15325.3	12097.71	11326.15	13383.49	11561.97	16127.63	13495.92	11599.58	11494.26
DESeq	R. aegyptiacus	Transcriptome	8252.02	7399.58	6552.1	8564.33	8118.9	7344.65	8435.26	8509.29	6561.32
DESeq	R. aegyptiacus	Genome	4070.93	3975.66	2792.79	4076.33	3896.42	3772.63	4448.65	3792.66	3304.9

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	15325.3	13383.49	13495.92	-0.2	-0.18	0.01
7h	12097.71	11561.97	11599.58	-0.07	-0.06	0.0
23h	11326.15	16127.63	11494.26	0.51	0.02	-0.49

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	15325.3	12097.71	11326.15	-0.34	-0.44	-0.1
Ebov	13383.49	11561.97	16127.63	-0.21	0.27	0.48
Marv	13495.92	11599.58	11494.26	-0.22	-0.23	-0.01

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8252.02	8564.33	8435.26	0.05	0.03	-0.02
7h	7399.58	8118.9	8509.29	0.13	0.2	0.07
23h	6552.1	7344.65	6561.32	0.16	0.0	-0.16

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8252.02	7399.58	6552.1	-0.16	-0.33	-0.18
Ebov	8564.33	8118.9	7344.65	-0.08	-0.22	-0.14
Marv	8435.26	8509.29	6561.32	0.01	-0.36	-0.38

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material