HIF1A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HIF1A MOP1, HIF-1alpha, PASD8, HIF1, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) NM_001530 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

The gene is constantly expressed in human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome881 765 755 743 894 1105 948 816 680
Read_Max
batR. aegyptiacusTranscriptome 795 700 409 733 578 579 577 962 566
Read_Max
bat_genomeR. aegyptiacusGenome 538 503 246 508 322 229 365 670 459
DESeq
humanH. sapiensGenome 15325.3 12097.71 11326.15 13383.49 11561.97 16127.63 13495.92 11599.58 11494.26
DESeq
batR. aegyptiacusTranscriptome 8252.02 7399.58 6552.1 8564.33 8118.9 7344.65 8435.26 8509.29 6561.32
DESeq
bat_genomeR. aegyptiacusGenome 4070.93 3975.66 2792.79 4076.33 3896.42 3772.63 4448.65 3792.66 3304.9

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 15325.3 13383.49 13495.92 -0.2 -0.18 0.01
7h 12097.71 11561.97 11599.58 -0.07 -0.06 0.0
23h 11326.15 16127.63 11494.26 0.51 0.02 -0.49

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 15325.3 12097.71 11326.15 -0.34 -0.44 -0.1
Ebov 13383.49 11561.97 16127.63 -0.21 0.27 0.48
Marv 13495.92 11599.58 11494.26 -0.22 -0.23 -0.01

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8252.02 8564.33 8435.26 0.05 0.03 -0.02
7h 7399.58 8118.9 8509.29 0.13 0.2 0.07
23h 6552.1 7344.65 6561.32 0.16 0.0 -0.16

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8252.02 7399.58 6552.1 -0.16 -0.33 -0.18
Ebov 8564.33 8118.9 7344.65 -0.08 -0.22 -0.14
Marv 8435.26 8509.29 6561.32 0.01 -0.36 -0.38