GRK5
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| GRK5 | RP11-714M16.1, GPRK5 | G protein-coupled receptor kinase 5 | NM_005308 |  |
 |
NONE |  |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
In human cells the gene is after 7 h in all samples upregulated, after 23 h the expression level is only downregulated in infected samples. In bat cells the expression level is stable in all control samples, in infected samples the expression level increases. %%%%%%%%%%%%%%%%%%%%%
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 66 | 92 | 96 | 64 | 92 | 63 | 89 | 125 | 70 |
Read_Max |  | R. aegyptiacus | Transcriptome | 62 | 65 | 70 | 69 | 69 | 112 | 48 | 95 | 99 |
Read_Max |  | R. aegyptiacus | Genome | 93 | 77 | 61 | 65 | 62 | 65 | 43 | 110 | 116 |
DESeq | | H. sapiens | Genome | 934.6 | 1174.87 | 1141.76 | 1169.06 | 1153.76 | 976.1 | 1027.33 | 1149.67 | 1117.71 |
DESeq | | R. aegyptiacus | Transcriptome | 625.22 | 610.97 | 841.42 | 749.1 | 832.17 | 927.46 | 588.35 | 809.03 | 949.18 |
DESeq | | R. aegyptiacus | Genome | 1816.75 | 1716.76 | 1807.56 | 1705.38 | 1961.05 | 2262.28 | 1763.27 | 1629.5 | 2061.71 |