RPS6KB2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RPS6KB2	KLS, P70-BETA, p70S6Kb, STK14B,p70S6Kb, KLS	ribosomal protein S6 kinase, 70kDa, polypeptide 2	NM_003952	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

It is expressed constantly at low level in both human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	149	212	236	195	319	289	240	280	235
Read_Max	R. aegyptiacus	Transcriptome	70	71	61	38	41	63	34	58	64
Read_Max	R. aegyptiacus	Genome	105	67	62	91	42	39	39	111	103
DESeq	H. sapiens	Genome	1501.87	1758.24	1542.86	1783.89	1566.74	1931.46	1712.43	1697.22	1555.91
DESeq	R. aegyptiacus	Transcriptome	315.21	340.48	269.74	216.18	224.4	246.09	226.82	244.73	260.79
DESeq	R. aegyptiacus	Genome	630.79	490.11	485.36	735.68	468.78	480.39	447.56	492.42	523.13

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1501.87	1783.89	1712.43	0.25	0.19	-0.06
7h	1758.24	1566.74	1697.22	-0.17	-0.05	0.12
23h	1542.86	1931.46	1555.91	0.32	0.01	-0.31

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1501.87	1758.24	1542.86	0.23	0.04	-0.19
Ebov	1783.89	1566.74	1931.46	-0.19	0.11	0.3
Marv	1712.43	1697.22	1555.91	-0.01	-0.14	-0.13

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	315.21	216.18	226.82	-0.54	-0.47	0.07
7h	340.48	224.4	244.73	-0.6	-0.48	0.13
23h	269.74	246.09	260.79	-0.13	-0.05	0.08

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	315.21	340.48	269.74	0.11	-0.22	-0.34
Ebov	216.18	224.4	246.09	0.05	0.19	0.13
Marv	226.82	244.73	260.79	0.11	0.2	0.09

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material