RPS6KB2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
RPS6KB2 KLS, P70-BETA, p70S6Kb, STK14B,p70S6Kb, KLS ribosomal protein S6 kinase, 70kDa, polypeptide 2 NM_003952 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

It is expressed constantly at low level in both human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome149 212 236 195 319 289 240 280 235
Read_Max
batR. aegyptiacusTranscriptome 70 71 61 38 41 63 34 58 64
Read_Max
bat_genomeR. aegyptiacusGenome 105 67 62 91 42 39 39 111 103
DESeq
humanH. sapiensGenome 1501.87 1758.24 1542.86 1783.89 1566.74 1931.46 1712.43 1697.22 1555.91
DESeq
batR. aegyptiacusTranscriptome 315.21 340.48 269.74 216.18 224.4 246.09 226.82 244.73 260.79
DESeq
bat_genomeR. aegyptiacusGenome 630.79 490.11 485.36 735.68 468.78 480.39 447.56 492.42 523.13

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1501.87 1783.89 1712.43 0.25 0.19 -0.06
7h 1758.24 1566.74 1697.22 -0.17 -0.05 0.12
23h 1542.86 1931.46 1555.91 0.32 0.01 -0.31

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1501.87 1758.24 1542.86 0.23 0.04 -0.19
Ebov 1783.89 1566.74 1931.46 -0.19 0.11 0.3
Marv 1712.43 1697.22 1555.91 -0.01 -0.14 -0.13

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 315.21 216.18 226.82 -0.54 -0.47 0.07
7h 340.48 224.4 244.73 -0.6 -0.48 0.13
23h 269.74 246.09 260.79 -0.13 -0.05 0.08

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 315.21 340.48 269.74 0.11 -0.22 -0.34
Ebov 216.18 224.4 246.09 0.05 0.19 0.13
Marv 226.82 244.73 260.79 0.11 0.2 0.09