NCK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NCK1 NCK Adaptor Protein 1, Melanoma NCK Protein, NCKalpha,NCKalpha NCK adaptor protein 1 NM_006153 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.

Expression in all samples, in human cells after Marburg infection it is downregulated at both timepoints.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome69 85 95 56 115 117 112 98 88
Read_Max
batR. aegyptiacusTranscriptome 117 97 75 114 119 117 117 138 117
Read_Max
bat_genomeR. aegyptiacusGenome 141 117 65 96 74 70 102 164 131
DESeq
humanH. sapiensGenome 677.86 688.39 771.43 650.05 735.09 735.28 754.52 661.26 779.54
DESeq
batR. aegyptiacusTranscriptome 719.32 572.84 702.16 760.09 746.76 695.2 736.3 747.89 718.26
DESeq
bat_genomeR. aegyptiacusGenome 935.88 856.1 868.08 740.61 798.04 853.74 909.75 844.49 822.8

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 677.86 650.05 754.52 -0.06 0.15 0.22
7h 688.39 735.09 661.26 0.09 -0.06 -0.15
23h 771.43 735.28 779.54 -0.07 0.02 0.08

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 677.86 688.39 771.43 0.02 0.19 0.16
Ebov 650.05 735.09 735.28 0.18 0.18 0.0
Marv 754.52 661.26 779.54 -0.19 0.05 0.24

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 719.32 760.09 736.3 0.08 0.03 -0.05
7h 572.84 746.76 747.89 0.38 0.38 0.0
23h 702.16 695.2 718.26 -0.01 0.03 0.05

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 719.32 572.84 702.16 -0.33 -0.03 0.29
Ebov 760.09 746.76 695.2 -0.03 -0.13 -0.1
Marv 736.3 747.89 718.26 0.02 -0.04 -0.06