NEDD4

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NEDD4	KIAA0093, MGC176705, NEDD4-1, RPF1	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	NM_198400	pdf		NONE

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Description

The long isoform is predominant in all samples. Expressen is also present upstream to the 5 prime start site. In the bat homolog the gene is downregulated in the control condition.

Homo sapiens neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4), transcript variant 3, mRNA.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	139	151	166	119	190	385	156	224	159
Read_Max	R. aegyptiacus	Transcriptome	1060	864	351	709	610	607	729	827	476
Read_Max	R. aegyptiacus	Genome	1173	759	284	786	531	362	633	1028	524
DESeq	H. sapiens	Genome	2714.54	2764.86	3425.25	2431.8	2935.75	6335.85	2394.89	2523.75	3610.99
DESeq	R. aegyptiacus	Transcriptome	17194.47	14021.18	8550.54	14256.12	14324.78	12392.69	16398.98	13411.19	8269.62
DESeq	R. aegyptiacus	Genome	23011.03	18504.69	10807.42	19637.1	18963.11	16996.44	22090.31	17382.96	11378.79

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2714.54	2431.8	2394.89	-0.16	-0.18	-0.02
7h	2764.86	2935.75	2523.75	0.09	-0.13	-0.22
23h	3425.25	6335.85	3610.99	0.89	0.08	-0.81

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2714.54	2764.86	3425.25	0.03	0.34	0.31
Ebov	2431.8	2935.75	6335.85	0.27	1.38	1.11
Marv	2394.89	2523.75	3610.99	0.08	0.59	0.52

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	17194.47	14256.12	16398.98	-0.27	-0.07	0.2
7h	14021.18	14324.78	13411.19	0.03	-0.06	-0.1
23h	8550.54	12392.69	8269.62	0.54	-0.05	-0.58

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	17194.47	14021.18	8550.54	-0.29	-1.01	-0.71
Ebov	14256.12	14324.78	12392.69	0.01	-0.2	-0.21
Marv	16398.98	13411.19	8269.62	-0.29	-0.99	-0.7

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material