PPARG

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PPARG	GLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARgamma, ppary,PPARG1	peroxisome proliferator-activated receptor gamma	NM_005037	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. The second-to-last intron in PPARG shows some clear expression. Otherwise it is expressed in both human and bat. There is very slight evidence for an increase in expression in human Ebola-infected cells after 23h, whereas this same sample shows a slight down-regulation in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	139	116	99	111	137	221	128	181	115
Read_Max	R. aegyptiacus	Transcriptome	60	57	29	43	45	37	42	53	37
Read_Max	R. aegyptiacus	Genome	66	67	28	55	32	25	41	68	46
DESeq	H. sapiens	Genome	1846.9	1272.78	1246.99	1649.29	1283.02	2248.6	1507.16	1335.12	1610.27
DESeq	R. aegyptiacus	Transcriptome	375.7	355.0	248.97	285.77	351.43	252.5	366.98	330.66	216.18
DESeq	R. aegyptiacus	Genome	572.35	554.0	469.74	559.9	578.16	419.04	562.27	514.62	381.01

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1846.9	1649.29	1507.16	-0.16	-0.29	-0.13
7h	1272.78	1283.02	1335.12	0.01	0.07	0.06
23h	1246.99	2248.6	1610.27	0.85	0.37	-0.48

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1846.9	1272.78	1246.99	-0.54	-0.57	-0.03
Ebov	1649.29	1283.02	2248.6	-0.36	0.45	0.81
Marv	1507.16	1335.12	1610.27	-0.17	0.1	0.27

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	375.7	285.77	366.98	-0.39	-0.03	0.36
7h	355.0	351.43	330.66	-0.01	-0.1	-0.09
23h	248.97	252.5	216.18	0.02	-0.2	-0.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	375.7	355.0	248.97	-0.08	-0.59	-0.51
Ebov	285.77	351.43	252.5	0.3	-0.18	-0.48
Marv	366.98	330.66	216.18	-0.15	-0.76	-0.61

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material