PPARG

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PPARG GLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARgamma, ppary,PPARG1 peroxisome proliferator-activated receptor gamma NM_005037 pdf NONE

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Description

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. The second-to-last intron in PPARG shows some clear expression. Otherwise it is expressed in both human and bat. There is very slight evidence for an increase in expression in human Ebola-infected cells after 23h, whereas this same sample shows a slight down-regulation in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome139 116 99 111 137 221 128 181 115
Read_Max
batR. aegyptiacusTranscriptome 60 57 29 43 45 37 42 53 37
Read_Max
bat_genomeR. aegyptiacusGenome 66 67 28 55 32 25 41 68 46
DESeq
humanH. sapiensGenome 1846.9 1272.78 1246.99 1649.29 1283.02 2248.6 1507.16 1335.12 1610.27
DESeq
batR. aegyptiacusTranscriptome 375.7 355.0 248.97 285.77 351.43 252.5 366.98 330.66 216.18
DESeq
bat_genomeR. aegyptiacusGenome 572.35 554.0 469.74 559.9 578.16 419.04 562.27 514.62 381.01

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1846.9 1649.29 1507.16 -0.16 -0.29 -0.13
7h 1272.78 1283.02 1335.12 0.01 0.07 0.06
23h 1246.99 2248.6 1610.27 0.85 0.37 -0.48

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1846.9 1272.78 1246.99 -0.54 -0.57 -0.03
Ebov 1649.29 1283.02 2248.6 -0.36 0.45 0.81
Marv 1507.16 1335.12 1610.27 -0.17 0.1 0.27

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 375.7 285.77 366.98 -0.39 -0.03 0.36
7h 355.0 351.43 330.66 -0.01 -0.1 -0.09
23h 248.97 252.5 216.18 0.02 -0.2 -0.22

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 375.7 355.0 248.97 -0.08 -0.59 -0.51
Ebov 285.77 351.43 252.5 0.3 -0.18 -0.48
Marv 366.98 330.66 216.18 -0.15 -0.76 -0.61