ERBB3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ERBB3 HER3 erb-b2 receptor tyrosine kinase 3 NM_001982 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

The gene is rather highly expressed in human cells in all conditions. The homolog in bat cells seems not to be expressed at all.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome460 482 571 484 652 484 577 510 441
Read_Max
batR. aegyptiacusTranscriptome NA 4 3 4 1 NA 3 2 3
Read_Max
bat_genomeR. aegyptiacusGenome 5 2 4 5 4 2 4 5 5
DESeq
humanH. sapiensGenome 13328.2 13688.71 15433.47 14460.3 13982.94 10477.06 14173.12 11672.32 11868.3
DESeq
batR. aegyptiacusTranscriptome 1.0 10.98 4.66 11.07 2.1 1.0 11.01 6.78 3.62
DESeq
bat_genomeR. aegyptiacusGenome 25.78 14.6 20.08 20.74 32.37 10.44 17.99 37.27 19.69

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 13328.2 14460.3 14173.12 0.12 0.09 -0.03
7h 13688.71 13982.94 11672.32 0.03 -0.23 -0.26
23h 15433.47 10477.06 11868.3 -0.56 -0.38 0.18

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 13328.2 13688.71 15433.47 0.04 0.21 0.17
Ebov 14460.3 13982.94 10477.06 -0.05 -0.46 -0.42
Marv 14173.12 11672.32 11868.3 -0.28 -0.26 0.02

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 11.07 11.01 3.47 3.46 -0.01
7h 10.98 2.1 6.78 -2.39 -0.7 1.69
23h 4.66 1.0 3.62 -2.22 -0.36 1.86

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 10.98 4.66 3.46 2.22 -1.24
Ebov 11.07 2.1 1.0 -2.4 -3.47 -1.07
Marv 11.01 6.78 3.62 -0.7 -1.6 -0.91