GSK3B

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GSK3B glycogen synthase kinase 3 beta pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The gene is expressed in all conditions.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome256 237 229 245 364 437 262 315 264
Read_Max
batR. aegyptiacusTranscriptome 736 480 369 536 405 596 483 525 545
Read_Max
bat_genomeR. aegyptiacusGenome 831 583 330 485 359 370 432 660 623
DESeq
humanH. sapiensGenome 6277.46 5403.27 5759.38 5713.54 6191.62 6929.33 5060.72 4657.22 7000.25
DESeq
batR. aegyptiacusTranscriptome 3457.34 3051.75 2834.97 3256.2 3233.71 3882.62 3469.48 3067.06 3034.49
DESeq
bat_genomeR. aegyptiacusGenome 10566.2 10112.55 8870.43 9636.85 10598.81 12637.67 11652.4 9372.62 9707.5

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6277.46 5713.54 5060.72 -0.14 -0.31 -0.18
7h 5403.27 6191.62 4657.22 0.2 -0.21 -0.41
23h 5759.38 6929.33 7000.25 0.27 0.28 0.01

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6277.46 5403.27 5759.38 -0.22 -0.12 0.09
Ebov 5713.54 6191.62 6929.33 0.12 0.28 0.16
Marv 5060.72 4657.22 7000.25 -0.12 0.47 0.59

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3457.34 3256.2 3469.48 -0.09 0.01 0.09
7h 3051.75 3233.71 3067.06 0.08 0.01 -0.08
23h 2834.97 3882.62 3034.49 0.45 0.1 -0.36

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3457.34 3051.75 2834.97 -0.18 -0.29 -0.11
Ebov 3256.2 3233.71 3882.62 -0.01 0.25 0.26
Marv 3469.48 3067.06 3034.49 -0.18 -0.19 -0.02