INPP5E

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
INPP5E	INP5E_HUMAN, NM_019892, NP_063945, Q15734, Q6PIV5, Q9NRR6,PPI5PIV, CORS1	inositol polyphosphate-5-phosphatase, 72 kDa	NM_019892	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

This gene is not differentially expressed in all probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	17	34	25	25	34	122	38	36	21
Read_Max	R. aegyptiacus	Transcriptome	37	36	27	31	31	22	31	38	40
Read_Max	R. aegyptiacus	Genome	81	58	42	61	43	27	38	67	72
DESeq	H. sapiens	Genome	419.09	514.0	390.19	493.78	422.11	1593.27	574.69	558.95	417.45
DESeq	R. aegyptiacus	Transcriptome	328.65	369.52	344.25	370.93	320.77	252.5	359.19	312.48	336.01
DESeq	R. aegyptiacus	Genome	896.34	951.02	928.33	1061.54	911.88	734.95	882.76	857.17	930.68

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	419.09	493.78	574.69	0.24	0.46	0.22
7h	514.0	422.11	558.95	-0.28	0.12	0.41
23h	390.19	1593.27	417.45	2.03	0.1	-1.93

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	419.09	514.0	390.19	0.29	-0.1	-0.4
Ebov	493.78	422.11	1593.27	-0.23	1.69	1.92
Marv	574.69	558.95	417.45	-0.04	-0.46	-0.42

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	328.65	370.93	359.19	0.17	0.13	-0.05
7h	369.52	320.77	312.48	-0.2	-0.24	-0.04
23h	344.25	252.5	336.01	-0.45	-0.03	0.41

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	328.65	369.52	344.25	0.17	0.07	-0.1
Ebov	370.93	320.77	252.5	-0.21	-0.55	-0.35
Marv	359.19	312.48	336.01	-0.2	-0.1	0.1

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material