RPTOR

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RPTOR	KOG1, Mip1,raptor, KIAA1303, raptor	regulatory associated protein of MTOR, complex 1	NM_020761	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.

RPTOR is expressed in human and so is its homolog in bat. In human, Ebola-infected cells are slightly up-regulated after 7h and 23h of infection, whereas in Marburg-infected cells there is a slight up-regulation after 7h, after which expression drops down again after 23h. In bat, the homolog shows no change in expression in Ebola-infected cells, but is up-regulated in Marburg-infected cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	73	101	80	89	132	226	105	154	93
Read_Max	R. aegyptiacus	Transcriptome	80	87	52	55	77	78	50	75	109
Read_Max	R. aegyptiacus	Genome	91	58	46	67	68	47	44	91	123
DESeq	H. sapiens	Genome	2479.11	2829.11	2288.47	2513.92	2607.32	5521.29	2670.33	2942.61	2370.33
DESeq	R. aegyptiacus	Transcriptome	1055.38	1034.86	907.38	861.73	1076.38	1182.81	1017.74	931.31	1059.4
DESeq	R. aegyptiacus	Genome	1689.56	1507.76	1432.66	1739.95	1621.74	1780.58	1608.08	1483.6	1583.1

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2479.11	2513.92	2670.33	0.02	0.11	0.09
7h	2829.11	2607.32	2942.61	-0.12	0.06	0.17
23h	2288.47	5521.29	2370.33	1.27	0.05	-1.22

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2479.11	2829.11	2288.47	0.19	-0.12	-0.31
Ebov	2513.92	2607.32	5521.29	0.05	1.14	1.08
Marv	2670.33	2942.61	2370.33	0.14	-0.17	-0.31

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1055.38	861.73	1017.74	-0.29	-0.05	0.24
7h	1034.86	1076.38	931.31	0.06	-0.15	-0.21
23h	907.38	1182.81	1059.4	0.38	0.22	-0.16

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1055.38	1034.86	907.38	-0.03	-0.22	-0.19
Ebov	861.73	1076.38	1182.81	0.32	0.46	0.14
Marv	1017.74	931.31	1059.4	-0.13	0.06	0.19

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material