NEDD4L

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NEDD4L	NEDD4-2, NEDD4.2, RSP5, hNEDD4-2,KIAA0439, NEDD4-2	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension.

The gene is upregulated in human cells Marburg infected cells after 23 h and 3 fold in Ebola infected cells after 23 h. The 3' UTR of Ebola infected cells after 23 h is truncated. The bat cells homolog is relatively uniformly expressed and it has a retained intron.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	188	146	130	151	210	539	224	214	126
Read_Max	R. aegyptiacus	Transcriptome	155	124	86	117	127	154	69	115	112
Read_Max	R. aegyptiacus	Genome	169	118	68	122	108	98	68	153	158
DESeq	H. sapiens	Genome	3848.06	3277.85	3179.03	3590.73	3249.55	8301.84	3544.03	2924.22	3154.31
DESeq	R. aegyptiacus	Transcriptome	1703.12	1544.07	1279.95	1422.12	1242.83	2218.34	1295.84	1226.27	1571.98
DESeq	R. aegyptiacus	Genome	2590.2	2331.91	2393.34	2331.45	2195.44	3485.44	2231.07	2050.56	2548.03

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3848.06	3590.73	3544.03	-0.1	-0.12	-0.02
7h	3277.85	3249.55	2924.22	-0.01	-0.16	-0.15
23h	3179.03	8301.84	3154.31	1.38	-0.01	-1.4

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3848.06	3277.85	3179.03	-0.23	-0.28	-0.04
Ebov	3590.73	3249.55	8301.84	-0.14	1.21	1.35
Marv	3544.03	2924.22	3154.31	-0.28	-0.17	0.11

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1703.12	1422.12	1295.84	-0.26	-0.39	-0.13
7h	1544.07	1242.83	1226.27	-0.31	-0.33	-0.02
23h	1279.95	2218.34	1571.98	0.79	0.3	-0.5

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1703.12	1544.07	1279.95	-0.14	-0.41	-0.27
Ebov	1422.12	1242.83	2218.34	-0.19	0.64	0.84
Marv	1295.84	1226.27	1571.98	-0.08	0.28	0.36

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material