INPP5D

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
INPP5D SHIP1,SHIP, hp51CN inositol polyphosphate-5-phosphatase, 145kDa NM_001017915 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.

The gene is not expressed in all measured conditions.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome0 2 1 2 2 0 2 1 2
Read_Max
batR. aegyptiacusTranscriptome NA 2 NA NA 1 NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 2 2 2 2 1 2 2 0 5
DESeq
humanH. sapiensGenome 1.0 1.0 1.99 1.0 1.0 1.0 1.0 1.0 1.0
DESeq
batR. aegyptiacusTranscriptome 1.0 2.82 1.0 1.0 2.1 1.0 1.0 1.0 1.0
DESeq
bat_genomeR. aegyptiacusGenome 1.72 3.65 2.23 1.97 2.23 5.22 5.62 0.0 12.84

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 1.0 1.0 1.0 0.0 0.0 0.0
23h 1.99 1.0 1.0 -0.99 -0.99 0.0

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.99 0.0 0.99 0.99
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 1.0 1.0 1.0 0.0 0.0 0.0

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 2.82 2.1 1.0 -0.43 -1.5 -1.07
23h 1.0 1.0 1.0 0.0 0.0 0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 2.82 1.0 1.5 0.0 -1.5
Ebov 1.0 2.1 1.0 1.07 0.0 -1.07
Marv 1.0 1.0 1.0 0.0 0.0 0.0