GBF1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GBF1 ARF1GEF,KIAA0248, ARF1GEF golgi brefeldin A resistant guanine nucleotide exchange factor 1 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication.

The gene is upregulated in Ebola infected cells after 23 h. The bat cells homolog is uniformly expressed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome289 315 271 241 330 476 321 344 230
Read_Max
batR. aegyptiacusTranscriptome 132 105 107 145 110 132 78 141 138
Read_Max
bat_genomeR. aegyptiacusGenome 142 153 91 106 96 80 70 174 157
DESeq
humanH. sapiensGenome 8715.99 8062.08 7602.07 7116.58 6968.8 12189.07 7171.27 7311.06 6124.94
DESeq
batR. aegyptiacusTranscriptome 2907.89 2764.01 3053.62 2890.85 2791.29 3137.1 2223.59 2866.29 2752.83
DESeq
bat_genomeR. aegyptiacusGenome 3441.0 3389.71 3497.96 3477.92 3367.38 3721.72 2606.67 3319.27 3296.34

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8715.99 7116.58 7171.27 -0.29 -0.28 0.01
7h 8062.08 6968.8 7311.06 -0.21 -0.14 0.07
23h 7602.07 12189.07 6124.94 0.68 -0.31 -0.99

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8715.99 8062.08 7602.07 -0.11 -0.2 -0.08
Ebov 7116.58 6968.8 12189.07 -0.03 0.78 0.81
Marv 7171.27 7311.06 6124.94 0.03 -0.23 -0.26

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2907.89 2890.85 2223.59 -0.01 -0.39 -0.38
7h 2764.01 2791.29 2866.29 0.01 0.05 0.04
23h 3053.62 3137.1 2752.83 0.04 -0.15 -0.19

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2907.89 2764.01 3053.62 -0.07 0.07 0.14
Ebov 2890.85 2791.29 3137.1 -0.05 0.12 0.17
Marv 2223.59 2866.29 2752.83 0.37 0.31 -0.06