GBF1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
GBF1	ARF1GEF,KIAA0248, ARF1GEF	golgi brefeldin A resistant guanine nucleotide exchange factor 1		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication.

The gene is upregulated in Ebola infected cells after 23 h. The bat cells homolog is uniformly expressed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	289	315	271	241	330	476	321	344	230
Read_Max	R. aegyptiacus	Transcriptome	132	105	107	145	110	132	78	141	138
Read_Max	R. aegyptiacus	Genome	142	153	91	106	96	80	70	174	157
DESeq	H. sapiens	Genome	8715.99	8062.08	7602.07	7116.58	6968.8	12189.07	7171.27	7311.06	6124.94
DESeq	R. aegyptiacus	Transcriptome	2907.89	2764.01	3053.62	2890.85	2791.29	3137.1	2223.59	2866.29	2752.83
DESeq	R. aegyptiacus	Genome	3441.0	3389.71	3497.96	3477.92	3367.38	3721.72	2606.67	3319.27	3296.34

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8715.99	7116.58	7171.27	-0.29	-0.28	0.01
7h	8062.08	6968.8	7311.06	-0.21	-0.14	0.07
23h	7602.07	12189.07	6124.94	0.68	-0.31	-0.99

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8715.99	8062.08	7602.07	-0.11	-0.2	-0.08
Ebov	7116.58	6968.8	12189.07	-0.03	0.78	0.81
Marv	7171.27	7311.06	6124.94	0.03	-0.23	-0.26

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2907.89	2890.85	2223.59	-0.01	-0.39	-0.38
7h	2764.01	2791.29	2866.29	0.01	0.05	0.04
23h	3053.62	3137.1	2752.83	0.04	-0.15	-0.19

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2907.89	2764.01	3053.62	-0.07	0.07	0.14
Ebov	2890.85	2791.29	3137.1	-0.05	0.12	0.17
Marv	2223.59	2866.29	2752.83	0.37	0.31	-0.06

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material