Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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PIP5K1A

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
PIP5K1A		phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	NM_003557	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type I, alpha(PIP5K1A), transcript variant 1, mRNA.

The gene is 2-fold upregulated in human cells 23 h after Ebolainfection and downregulated 23 h after Marburg infection. The bat cells homologis not expressed without any significant changes.}

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source		Species	Mapping on	Mock3h	Mock7h	Mock23h	EBOV3h	EBOV7h	EBOV23h	MARV3h	MARV7h	MARV23h
Read_Max		H. sapiens	Genome	488	554	317	483	461	1111	633	643	324
Read_Max		R. aegyptiacus	Transcriptome	164	126	123	171	140	246	122	200	184
Read_Max		R. aegyptiacus	Genome	194	174	125	139	154	154	107	252	211
DESeq		H. sapiens	Genome	5242.37	4806.64	4184.76	5270.96	4889.27	12270.66	5468.62	4892.23	4176.41
DESeq		R. aegyptiacus	Transcriptome	1200.72	1125.63	1345.91	1280.19	1284.45	2014.31	1154.57	1403.08	1307.81
DESeq		R. aegyptiacus	Genome	2782.71	2730.75	3155.42	2573.38	2673.14	4395.32	2545.94	2879.19	2815.16

Human Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	5242.37	5270.96	5468.62	0.01	0.06	0.05
7h	4806.64	4889.27	4892.23	0.02	0.03	0.0
23h	4184.76	12270.66	4176.41	1.55	-0.0	-1.55

Human Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	5242.37	4806.64	4184.76	-0.13	-0.33	-0.2
Ebov	5270.96	4889.27	12270.66	-0.11	1.22	1.33
Marv	5468.62	4892.23	4176.41	-0.16	-0.39	-0.23

Bat Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	1200.72	1280.19	1154.57	0.09	-0.06	-0.15
7h	1125.63	1284.45	1403.08	0.19	0.32	0.13
23h	1345.91	2014.31	1307.81	0.58	-0.04	-0.62

Bat Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	1200.72	1125.63	1345.91	-0.09	0.16	0.26
Ebov	1280.19	1284.45	2014.31	0.0	0.65	0.65
Marv	1154.57	1403.08	1307.81	0.28	0.18	-0.1