OFD1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
OFD1	71-7A, CXorf5, JBTS10, RP23, SGBS2	oral-facial-digital syndrome 1	NM_003611	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome. Alternatively spliced transcripts have been described for this gene but the biological validity of these transcripts has not been determined.

There is a downregulation in human cells Marburg infected cells after 23 h. Homolog in bat cells is stably expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	53	50	44	42	64	88	75	75	51
Read_Max	R. aegyptiacus	Transcriptome	114	110	96	108	84	119	90	139	137
Read_Max	R. aegyptiacus	Genome	121	104	82	100	72	65	75	182	134
DESeq	H. sapiens	Genome	877.78	824.04	994.82	931.8	968.41	1465.62	946.63	859.5	1218.83
DESeq	R. aegyptiacus	Transcriptome	1255.33	1222.75	1347.13	1327.8	1266.92	1461.26	1249.12	1326.24	1315.69
DESeq	R. aegyptiacus	Genome	2508.56	2686.94	2731.42	2349.22	2485.63	2938.48	2493.09	2808.61	2631.08

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	877.78	931.8	946.63	0.09	0.11	0.02
7h	824.04	968.41	859.5	0.23	0.06	-0.17
23h	994.82	1465.62	1218.83	0.56	0.29	-0.27

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	877.78	824.04	994.82	-0.09	0.18	0.27
Ebov	931.8	968.41	1465.62	0.06	0.65	0.6
Marv	946.63	859.5	1218.83	-0.14	0.36	0.5

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1255.33	1327.8	1249.12	0.08	-0.01	-0.09
7h	1222.75	1266.92	1326.24	0.05	0.12	0.07
23h	1347.13	1461.26	1315.69	0.12	-0.03	-0.15

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1255.33	1222.75	1347.13	-0.04	0.1	0.14
Ebov	1327.8	1266.92	1461.26	-0.07	0.14	0.21
Marv	1249.12	1326.24	1315.69	0.09	0.07	-0.01

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material