PFN1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| PFN1 | Profilin, ALS18 | profilin 1 | NM_005022 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease.
The highly expressed gene is upregulated in bat cells Marburg infected cells but down in human cells Ebola infected cells after 23 h.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 1165 | 1264 | 952 | 1256 | 1410 | 1305 | 1599 | 1838 | 1052 |
Read_Max |  | R. aegyptiacus | Transcriptome | 2252 | 2401 | 1807 | 1893 | 1554 | 2087 | 2265 | 2073 | 2996 |
Read_Max |  | R. aegyptiacus | Genome | 2461 | 1968 | 1550 | 2278 | 1418 | 1172 | 1915 | 2767 | 3280 |
DESeq | | H. sapiens | Genome | 5207.87 | 5141.16 | 3608.92 | 5461.45 | 4385.24 | 4508.03 | 5700.2 | 5553.29 | 4290.58 |
DESeq | | R. aegyptiacus | Transcriptome | 6801.94 | 7817.12 | 7524.44 | 6205.57 | 6118.17 | 6704.34 | 8087.08 | 6152.12 | 8460.31 |
DESeq | | R. aegyptiacus | Genome | 7373.57 | 6860.65 | 7611.84 | 9131.26 | 6888.78 | 7100.12 | 9208.79 | 6719.42 | 8578.18 |