ITCH

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ITCH	AIF4, AIP4, NAPP1, dJ468O1.1,AIP4	itchy E3 ubiquitin protein ligase		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses.

Expression in human cells is increased upon early Ebola infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	376	328	322	306	474	619	452	371	326
Read_Max	R. aegyptiacus	Transcriptome	304	244	176	342	250	276	261	359	234
Read_Max	R. aegyptiacus	Genome	310	279	146	224	199	154	208	387	250
DESeq	H. sapiens	Genome	7268.9	6166.13	7033.18	6539.4	6613.54	9808.57	6210.73	5291.9	6986.12
DESeq	R. aegyptiacus	Transcriptome	3907.65	3344.02	2968.11	3903.58	3900.62	3945.5	4070.18	3831.3	3065.98
DESeq	R. aegyptiacus	Genome	4918.29	4527.83	3580.53	4270.87	4646.47	4994.5	5021.04	4683.93	3846.01

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7268.9	6539.4	6210.73	-0.15	-0.23	-0.07
7h	6166.13	6613.54	5291.9	0.1	-0.22	-0.32
23h	7033.18	9808.57	6986.12	0.48	-0.01	-0.49

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7268.9	6166.13	7033.18	-0.24	-0.05	0.19
Ebov	6539.4	6613.54	9808.57	0.02	0.58	0.57
Marv	6210.73	5291.9	6986.12	-0.23	0.17	0.4

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3907.65	3903.58	4070.18	-0.0	0.06	0.06
7h	3344.02	3900.62	3831.3	0.22	0.2	-0.03
23h	2968.11	3945.5	3065.98	0.41	0.05	-0.36

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3907.65	3344.02	2968.11	-0.22	-0.4	-0.17
Ebov	3903.58	3900.62	3945.5	-0.0	0.02	0.02
Marv	4070.18	3831.3	3065.98	-0.09	-0.41	-0.32

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material