LDLRAP1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
LDLRAP1 ARH, ARH1, ARH2, FHCB1, FHCB2, MGC34705, DKFZp586D0624 low density lipoprotein receptor adaptor protein 1 NM_015627 pdf

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Description

The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.The first exon seems to be less expressed in human EBOV and MARV 23h, where the gene is also downregulated. In bat, the gene is downregulated in early EBOV infection, and upregulated in late MARV infection. The first exons also appears to be even further downregulated in bat EBOV 23h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome36 29 39 30 48 26 46 60 27
Read_Max
batR. aegyptiacusTranscriptome 92 110 84 68 62 71 56 76 166
Read_Max
bat_genomeR. aegyptiacusGenome 86 69 81 101 46 46 47 87 174
DESeq
humanH. sapiensGenome 609.87 698.59 734.7 645.49 657.05 270.76 708.03 765.98 657.76
DESeq
batR. aegyptiacusTranscriptome 537.01 552.88 782.78 438.69 463.13 525.82 419.26 445.5 861.71
DESeq
bat_genomeR. aegyptiacusGenome 1281.35 1106.17 1776.32 1339.03 1118.37 1313.24 1196.5 1147.39 2190.99

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 609.87 645.49 708.03 0.08 0.22 0.13
7h 698.59 657.05 765.98 -0.09 0.13 0.22
23h 734.7 270.76 657.76 -1.44 -0.16 1.28

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 609.87 698.59 734.7 0.2 0.27 0.07
Ebov 645.49 657.05 270.76 0.03 -1.25 -1.28
Marv 708.03 765.98 657.76 0.11 -0.11 -0.22

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 537.01 438.69 419.26 -0.29 -0.36 -0.07
7h 552.88 463.13 445.5 -0.26 -0.31 -0.06
23h 782.78 525.82 861.71 -0.57 0.14 0.71

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 537.01 552.88 782.78 0.04 0.54 0.5
Ebov 438.69 463.13 525.82 0.08 0.26 0.18
Marv 419.26 445.5 861.71 0.09 1.04 0.95