LDLRAP1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| LDLRAP1 | ARH, ARH1, ARH2, FHCB1, FHCB2, MGC34705, DKFZp586D0624 | low density lipoprotein receptor adaptor protein 1 | NM_015627 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.The first exon seems to be less expressed in human EBOV and MARV 23h, where the gene is also downregulated. In bat, the gene is downregulated in early EBOV infection, and upregulated in late MARV infection. The first exons also appears to be even further downregulated in bat EBOV 23h.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 36 | 29 | 39 | 30 | 48 | 26 | 46 | 60 | 27 |
Read_Max |  | R. aegyptiacus | Transcriptome | 92 | 110 | 84 | 68 | 62 | 71 | 56 | 76 | 166 |
Read_Max |  | R. aegyptiacus | Genome | 86 | 69 | 81 | 101 | 46 | 46 | 47 | 87 | 174 |
DESeq | | H. sapiens | Genome | 609.87 | 698.59 | 734.7 | 645.49 | 657.05 | 270.76 | 708.03 | 765.98 | 657.76 |
DESeq | | R. aegyptiacus | Transcriptome | 537.01 | 552.88 | 782.78 | 438.69 | 463.13 | 525.82 | 419.26 | 445.5 | 861.71 |
DESeq | | R. aegyptiacus | Genome | 1281.35 | 1106.17 | 1776.32 | 1339.03 | 1118.37 | 1313.24 | 1196.5 | 1147.39 | 2190.99 |