ARF1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ARF1		ADP-ribosylation factor 1	NM_001024227	pdf

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Description

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Gene is highly but stably expressed in human. It shows insignificant upregulation upon bat MARV expression, and equally insignificant downregulation in bat EBOV data.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	753	903	893	877	1155	1043	1107	1167	871
Read_Max	R. aegyptiacus	Transcriptome	1929	2192	1392	1803	1564	1663	1408	2011	2077
Read_Max	R. aegyptiacus	Genome	2065	1583	1103	2035	1180	882	1074	2184	2080
DESeq	H. sapiens	Genome	7711.35	7834.64	6713.49	8247.0	6950.1	7075.4	8007.25	7646.79	8148.49
DESeq	R. aegyptiacus	Transcriptome	5973.56	6689.77	6004.85	6081.04	5936.39	6019.12	5955.71	5997.62	6212.31
DESeq	R. aegyptiacus	Genome	11826.07	10896.55	10445.91	13050.58	11450.42	11239.58	11953.78	10556.49	11651.06

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7711.35	8247.0	8007.25	0.1	0.05	-0.04
7h	7834.64	6950.1	7646.79	-0.17	-0.04	0.14
23h	6713.49	7075.4	8148.49	0.08	0.28	0.2

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7711.35	7834.64	6713.49	0.02	-0.2	-0.22
Ebov	8247.0	6950.1	7075.4	-0.25	-0.22	0.03
Marv	8007.25	7646.79	8148.49	-0.07	0.03	0.09

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5973.56	6081.04	5955.71	0.03	-0.0	-0.03
7h	6689.77	5936.39	5997.62	-0.17	-0.16	0.01
23h	6004.85	6019.12	6212.31	0.0	0.05	0.05

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5973.56	6689.77	6004.85	0.16	0.01	-0.16
Ebov	6081.04	5936.39	6019.12	-0.03	-0.01	0.02
Marv	5955.71	5997.62	6212.31	0.01	0.06	0.05

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material