AP2A1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| AP2A1 | ADTAA, AP2-ALPHA, CLAPA1 | adaptor-related protein complex 2, alpha 1 subunit |  |
 |
 |
 |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Expression in humans is up in EBOV 23 and down in MARV23. The central exons appear to be the reason for the upregulation. The bat homolog shows only slight variations.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 130 | 130 | 134 | 132 | 151 | 276 | 144 | 188 | 119 |
Read_Max |  | R. aegyptiacus | Transcriptome | 212 | 188 | 167 | 166 | 136 | 211 | 130 | 190 | 224 |
Read_Max |  | R. aegyptiacus | Genome | 256 | 225 | 168 | 259 | 141 | 131 | 143 | 262 | 287 |
DESeq | | H. sapiens | Genome | 2686.13 | 2398.72 | 2290.45 | 2454.61 | 2170.77 | 4751.48 | 2466.82 | 2599.69 | 2232.24 |
DESeq | | R. aegyptiacus | Transcriptome | 2744.06 | 2893.81 | 3146.46 | 2454.08 | 2356.54 | 2766.26 | 2518.37 | 2401.96 | 2859.55 |
DESeq | | R. aegyptiacus | Genome | 3090.37 | 2842.1 | 3442.17 | 3424.59 | 2636.31 | 3101.65 | 2847.32 | 2481.13 | 3090.85 |