CEP290

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CEP290	BBS14, CT87, NPHP6, JBTS5, LCA10, SLSN6, MKS4, POC3,KIAA0373, FLJ13615, 3H11Ag, rd16, BBS14	centrosomal protein 290kDa	NM_025114	pdf

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Description

The gene CEP290 is expressed in human and mouse datasets without significant changes in expression levels. It overlaps with the gene BC033323 which does not seem to be expressed. This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. (provided by RefSeq, Jul 2008)

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	49	62	64	50	79	80	66	70	78
Read_Max	R. aegyptiacus	Transcriptome	80	49	43	71	55	53	62	70	50
Read_Max	R. aegyptiacus	Genome	100	95	41	69	65	38	66	136	71
DESeq	H. sapiens	Genome	1786.01	1716.43	2362.93	1988.07	2184.59	2439.4	1851.02	1635.67	2903.13
DESeq	R. aegyptiacus	Transcriptome	896.59	688.12	775.45	1017.39	908.83	903.08	907.61	1046.15	777.74
DESeq	R. aegyptiacus	Genome	2707.94	3292.05	2123.33	2164.56	2925.39	2542.94	2791.09	3417.6	2268.91

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1786.01	1988.07	1851.02	0.15	0.05	-0.1
7h	1716.43	2184.59	1635.67	0.35	-0.07	-0.42
23h	2362.93	2439.4	2903.13	0.05	0.3	0.25

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1786.01	1716.43	2362.93	-0.06	0.4	0.46
Ebov	1988.07	2184.59	2439.4	0.14	0.3	0.16
Marv	1851.02	1635.67	2903.13	-0.18	0.65	0.83

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	896.59	1017.39	907.61	0.18	0.02	-0.16
7h	688.12	908.83	1046.15	0.4	0.6	0.2
23h	775.45	903.08	777.74	0.22	0.0	-0.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	896.59	688.12	775.45	-0.38	-0.21	0.17
Ebov	1017.39	908.83	903.08	-0.16	-0.17	-0.01
Marv	907.61	1046.15	777.74	0.2	-0.22	-0.43

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material